Term
| What effect does IV clonidine have on heart rate and BP? |
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Definition
| BP increases because it is an alpha 2 agonist and you have a reflexive bradycardia; then BP decreases b/c of CNS evoked inhibition of sympathetic outflow and heart rate doesn't compensate because sympathetics can't be activated |
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Term
| What are teh different ACh receptors? |
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Definition
nicotinic= N(n) and N(m)
muscarinic= M1, M2, M3 |
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Term
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Definition
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Term
| What happens if you give bolus of EPI + atropine? |
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Definition
| increase in BP because EPI is stimulating alphas but NO reflexive bradycardia because atropine is block muscarinic receptors. Instead you have tachycardia because of EPI on beta 1s |
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Term
| What happens if you give EPI bolus + atropine + phenoxybenzamine? |
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Definition
| decreased bp because alphas are blocked and EPI is stimulating beta 2s; heart rate increases b/c EPI and no baroreflex because of atropine |
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Term
| What happens if you give EPI bolus + atropine + phenoxybenzamine + practolol? |
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Definition
| no increase or decrease in heart rate because both alphas and betas are blocked; decrease in blood pressure because beta2s can stillwork |
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Term
| What effect does isoproterenol have on heart rate, contractile force, TPR and MAP? |
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Definition
| HR increase; force increase ;decrease TPR; normal to decrease MAP |
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Term
| What effect does NE have on HR, contractile force, TPR, and MAP? |
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Definition
| decrease rate, increase force, increase TPR, increase MAP |
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Term
| What effect does IV EPI bolus have on HR, contractile force, TPR, and MAP? |
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Definition
| decrease HR, increase force, increase TPR, and increase MAP |
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Term
| What effect does EPI infusion have on HR, force, TPR, and MAP? |
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Definition
| HR increase, force increase, TPR decrease, MAP increase to normal |
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Term
| What happens if you give a bolus of ACh? |
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Definition
| drop in BP with reflex tachycardia |
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Term
| What happens to BP and HR if you give atropine? |
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Definition
| increase heart rate and normal BP |
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Term
| Name a drug that can cause EPI reversal? |
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Definition
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Term
| What happens to blood pressure and heart rate if you give a bolus of ACh after atropine? |
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Definition
| early decrease in BP is d/t ACh overcoming dose of atropine(causing reflexive tachycardia), however eventually ACh reaches nicotinic receptors to increase sympathetics causing and increase in BP. |
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Term
| What drug can cause ACh reversal? |
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Definition
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Term
| What drugs can increase heart rate if you OD on a beta blocker? |
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Definition
| glucagon and caffiene (phosphodiesterase inhibitor)= goal is to increase cAMP |
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Term
| What happens at the tail end of an EPI bolus? |
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Definition
| vasodilation as concentration decreases |
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