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15 Muscle and Cell Communication
powerpoint lecture
41
Biology
Undergraduate 1
03/07/2011

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Term
Describe the series of events that occur to cause muscle excitation.
Definition

An action potential in a motor neuron makes a synapse with the muscle fiber.

That synapse releases the neurotransmitter acetylcholine which depolarizes the muscle and causes it to produce an action potential.

The action potentials travel to the interior of the muscle fiber along infoldings of the plasma membrane called transverse (T) tubules. this causes the sarcoplasmic reticulum to release Ca2+. The calcium ions result in movement of troponin and tropomyosin on their thin filaments, and this enables the myosin molecule heads to "grab and swivel" their way along the thin filament. This is the driving force of muscle contraction.

Term
Intercalated discs
Definition
connect striated cells of the cardiac muscle
Term
What type of muscle can generate action potentials without neural input?
Definition
Cardiac muscle
Term
Where is Smooth muscle typically found?
Definition
walls of hollow organs
Term
Stimulation from neurons in what system can cause smooth muscle to contract?
Definition
the autonomic nervous system
Term
What characteristics does the Skeletal muscle have that the smooth muscle does not?
Definition

sarcomeres

actin&myosin organized into thin and thick filaments

Term
In smooth muscle, how is contraction controlled?
Definition
by Ca++
Term
Actin&Myosin in smooth muscle vs. in striated muscle
Definition

smooth muscle actin and striated muscle actin are the same

 

Smooth muscle myosin is different than striated muscle myosin

- smooth muscle myosin will not interact with actin unless activated by phosphorylation

Term
The activation of myosin interacting with myosin requires phosphorylation. What enzyme is required for phosphorylation to occur?
Definition
Myosin Light Chain Kinase (MLCK)
Term
What activates the enzyme MLCK?
Definition
Ca ++
Term
Intercellular junctions
Definition

a category of ways in which cells interact, there are 4 types

Term
What connects the cytoplasm of one cell to the cytoplasm of another cell ?
Definition
the plasmodesmata
Term
What is the functional whole that is the connection of cytoplasm in plants?
Definition

the symplast

 

The symplast of a plant is the inner side of the plasma membrane in which water (and low-molecular solutes) can freely diffuse.

Term
What is the function of junctions in relation to basal lamina?
Definition
The basal lamina are attached to cells and attached to each other, the junctions prevent stuff from going down in between them.
Term
Tight junctions
Definition
hold cells close together and stop stuff from squeezing between them
Term
Desmosomes 
Definition

anchoring junctions, join intermediate filaments in one cell to those in a neighbor.

 

Cadherin protein joins through the membrane into a plate of anchor protein and then keratin filaments are anchored to the filaments in another cell

Term

Gap junctions 

 

Definition
similar to a plasmodesma , have a tube of cytoplasm called connexons that make an open channel between adjacent cells
Term
What are junctions created by?
Definition
PROTEINS!!!!! yayy
Term
All cells have a ring of _____ around them to prevent unwanted things from getting in.
Definition
junctions
Term
Adheren Junctions
Definition
a protein called cadherins joins actin of one cell to an actin bundle in another cell
Term
Why shouldn't you pick up a cone snail?
Definition

they are neurotoxic

It can paralyze small invertebrates in less than on second so that it can't transmit nerve impulses 

-This type of toxin can be used for different medical things like Alzheimer's, parkinsons', epilepsy or pain relief

- 1000 times more effective than morphine!

Term
What type of signals do neurons use to communicate?
Definition

electrical - to travel long distance, to ganglia, to your fingers to type

 

or 

chemical - at synapses electrical turns to chemical

Term
Plant cells have an extracellular structure made of cellulose fibers embedded in other polysaccharides and protein. What type of structure do animal cells have instead?
Definition
an elaborate matrix called the extracellular matrix which is made up of glycoproteins and other macromolecules
Term
Fibroblasts
Definition
A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals.
Term
Where do you find a lot of ganglia in humans?
Definition
around the spinal column and brain
Term
Instead of having a brain, insects have what?
Definition
a collection of ganglia...which are a collection of neurons
Term
Describe where you'd find sensory neurons, and how sensory information is acquired and travels. 
Definition

Find them in eyes, ears, nose, fingertips... and they detect what is going on outside

 

Sensory information is picked up, turned into electrical impulse and travels along as a sensory neuron, goes to the brain then interneurons inegrate the information and the motor output leaves the brain or ganglia via motor neurons which react to the sensory information

Term
Where do you find motor neurons?
Definition
in the peripheral nervous system
Term
What happens to signals at the synapse?
Definition
electrical signals become chemical signals
Term
What is a synapse?
Definition
a junction between an axon and another cell
Term
What to the vesicles in synaptical terminals contain?
Definition
neurotransmitters such as amino acids
Term

End of an axon is a _____ cell (one with the vesicles), they release their info to a ________(like a muscle or gland)

Definition
pre-synaptic, post-synaptic
Term
what is a nerve impulse?
Definition
A wave of destruction of the membrane potential 
Term
When you depolarize the membrane, what happens to the gated ion channels?
Definition
getting rid of the charge imbalance causes the gate to open, after a while it gets tired and the lid closes, making it inactivated to they have returned to their normal resting phase
Term
All-or-nothing principle
Definition
A particular threshold voltage has to be reached in order for an action potential will occur 
Term
Action potentials
Definition
signals that carry info along axons
Term
The ____ of action potentials reflect the strength of a stimulus.
Definition
frequency
Term
What occurs during the rising phase?
Definition
the threshold is crossed and the membrane potential decreases
Term
What occurs during the falling phase?
Definition
the voltage gated sodium channels become inactivated, the voltage gated potassium channels open and potassium flows out of the cell
Term
Refractory period
Definition
occurs after an action potential, a second action potential can't happen during this time, and there is temporary inactivation of the sodium channels
Term
Describe 5 functions of the extracellular matrix
Definition

Support

Adhesion

Movement

Regulation

communication

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