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Glucose →→→ 2 glyceraldehyde-3-phosphate (G3P)(uses 2 ATP) |
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Glucose + ATP → G-6-P + ADP 6C->6C Hexokinase ATP-independent phospotransferase can also bring in G6P Energy carrier: -ATP |
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G-6-P ↔ Fructose-6-P 6C->6C Phosphoglucose isomerase |
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Fructose-6-P + ATP → Fructose-1,6-bisphosphate + ADP 6C-> 6C Phosphfructokinase Energy Carrier: -1 ATP |
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Fruc-1,6-2P ↔ Dihydroxyacetone phosphate (DHAP) + Glyceraldehyde-3-phosphate (G3P) 6C-> 3C +3C Aldolase |
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Dihydroxyacetone phosphate (DHAP) ↔ Glyceraldehyde-3-phosphate (G3P) 3C <-> 3C Triose phosphate isomerase (TIM) |
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G3P + NAD+ + Pi ↔ 1,3-bisphosphoglycerate + NADH + H+ 3C<->3C Glyceraldehyde 3 phosphate dehydrogenase Energy carrier= +1NADH |
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1,3-bisphosphoglycerate + ADP ↔ 3-phosphoglycerate (3PG) + ATP 3C<-> 3C Phophoglycerate kinase Energy carrier= +1ATP (substrate-level phosphorylation) |
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3-phosphoglycerate (3PG) ↔ 2-phosphoglycerate (2PG) 3C<->3C Phosphoglycerate mutase Shift of phosphate functional group |
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2-phosphoglycerate (2PG) → phosphoenolpyruvate (PEP) + H2O 3C<-> 3C enolase |
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Phosphoenolpyruvate (PEP) + ADP → pyruvate + ATP 3C<->3C Pyruvate kinase Energy carrier: +1ATP (substrate-level phosphorylation) |
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G3P → pyruvate (1NADH and 2 ATP per run) Stage 2 happens twice per glucose |
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