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Acid Base 3
Acid Base 3 Disturbances
16
Physiology
Undergraduate 4
11/25/2016

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Term
What is Actual Base Excess
Definition
Amount of strong acid that must be added to 1L of fully oxygenated blood to return pH to 7.40, at 37 Celsius and pCO2 of 40mmHg.
Term
What measure defines the metabolic component of an animal's acid-base status, taking in to account all factors that contribute to buffering capacity?
Definition
actual base excess (ABE)
Term
How can you tell if acidosis is metabolic or respiratory in origin?
Definition
normal or low pCO2 = metabolic
high pCO2 = respiratory

low Base Excess = metabolic
Term
How can you tell if alkalosis is metabolic or respiratory in origin?
Definition
low pCO2 = respiratory
high or normal pCO2 = metabolic

high Base Excess = metabolic
Term
If pCO2 is above 50mmHg, this indicates respiratory ______
Definition
acidosis
Term
If pCO2 is below 40mmHg, this indicates respiratory ______
Definition
alkalosis
Term
Hyperventilation can lead to respiratory ______
Definition
alkalosis
Term
What gas is the major determinant/indicator of respiratory acidosis
Definition
CO2
Term
What is the most common cause of acid-base imbalance
Definition
metabolic acidosis
Term
What is metabolic acidosis?
Definition
elevated blood pH and base excess due to anything other than decreased CO2
Term
How might the body compensate for metabolic acidosis?
Definition
-increased ventilation (higher resp rate & deeper breaths)
-pCO2 will then fall below normal (trying to raise blood pH)
Term
How might the body compensate for metabolic alkalosis?
Definition
-slow shallow breathing to try and conserve CO2 by decreasing ventilation
-eventually pCO2 will rise
Term
What are the signs of renal compensation for respiratory acidosis?
Definition
high bicarbonate levels bc kidneys will start retaining bicarbonate to offset acidosis
Term
Compensated respiratory alkalosis has (high/low) PCO2 and (high/low) pH, with (high/low) HCO3-.
Definition
low pCO2
high pH
low HCO3-
Term
Increased ketone production is a sign of....
Definition
metabolic acidosis
Term
How might chronic diarrhea affect acid-base balance?
Definition
lead to metabolic acidosis as excess buffer bases are lost
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