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adrenergic farm
adrenergic farmacology
20
Medical
Graduate
11/28/2011

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Term
catecholamines what are they
Definition
dopamine, norepinephrine, ephineprhine
Term
syntehtsis fo cateacholamines
Definition
tyrosine via tyrosine hydroxylase to dopa via dopa decarboxylase to dopamine via dopamine b hydroxylase to norepeinenrpiherine
Term
clearance of norep
Definition
most celeared via norepinerphinre transported which transports to presynaptic cell. Some trnasported to post synatpic cell via ENT (extraneuronal trnasporter) or OCT 3 (organic cation transporter 3) . Rest diffusesi nto circulation .
Term
catechoalmine metabolizesr
Definition
COMT, and mAO
Term
mao location
Definition
mitochondrial otuerm embrane
Term
comt location
Definition
nonneuronal cytosol
Term
net effect of catecholamien post release
Definition
most is reuptaken via net, and transported to storage vesicelsdue to higher affinity to vmat-2 than mao.
Term
metyrosine function
Definition
inhibits tyrosine hydroxylase and catecholamien syntehsis
Term
reserpine
Definition
blocks storage in vsicles
Term
Guanethdine function
Definition
blocks transmitter release
Term
antagonize receptors
Definition
alpha/beta blockers
Term
amphetamine and tyramine
Definition
indirect agonists which promote transmitter releasse
Term
cocaine, tricicylic antidepressants
Definition
block transmitter reuptake
Term
adrenergic agonists
Definition
activate receptors
Term
beta catecholamine receptor coupling
Definition
Gs positive instigation fo adencyl cyclaste wich increase camp and goesto PKA
Term
alpha 2 recpetor copuglign
Definition
geos to Gi which inhbiits adenyl cyclase which decrease camp which decreases PKA
Term
a1 receptr coupling
Definition
goes to Gq which goes to DAg increasing protein kinase c levels, and also geos to PIP2 and IP3 increasing calcium levels
Term
beta downstream effects
Definition
increase in camp promotes relaxation of smooth muscle.

on cardiac muscle: Beta Gs icnreases camp and promotes rate of caclium reuptake - increaasign contraction and increased chronotropic and ionotropic effects
Term
alpha 2 downstream effects
Definition
smooth muscle: will decrease cam pand cauase contraction - vasoconstriaction
Term
alpha 1 downstream effects on smooth muscle
Definition
will cause vasoconstriciton , due to increased calcium
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