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An S 352
Lectures after Exam 3
33
Agriculture
Undergraduate 2
05/01/2015

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Term
Biotechnology
Definition
the application of biological knowledge to practical needs
Term
1. Altering Reproduction
2. Gene Technologies
Definition
2 types of biotechnology
Term
1. Artificial Insemination
2. Estrus Synchronization
3. Multiple Ovulation
4. Embryo Transfer
5. Controlling Sex
6. Cloning
Definition
Altering Reproduction Methods
Term
1. Gene Mapping
2. Gene Transfer
3. Gene Deletion
4. Marker Assisted Selection
5. Whole Genome Selection
6. Sequencing
Definition
Gene Technology Methods
Term
Artificial Selection
Definition
semen collected from males then used in fresh or frozen form to breed females
Term
1. Increase selection intensity of males (need less males)
2. Increase accuracy of selection (lots of data on each sire)
3. May decrease generation interval (less time needed to collect data)
Definition
How artificial selection affects genetic change
Term
Estrus Synchronization
Definition
administration of hormones to a group of mammalian females causing them to come into heat (estrus) at or near the same time
Term
1. Slight decrease in generation interval of females (shorter breeding & calving season)
Definition
How estrus synchronization affects genetic change
Term
Multiple Ovulation
Definition
administration of a hormone causing a female to develop and release more eggs than normal
Term
Embryo Transfer
Definition
reproductive technology in which embryos from donor females are collected and transferred in fresh or frozen form to recipient female
Term
1. Increase intensity of selection of females (need less females to reproduce)
2. Decrease generation interval
3. Rapidly decrease genetic variation (bad) (offspring all from same dam)
Definition
How multiple ovulation and embryo tranfer (MOET) affects genetic change
Term
Cloning
Definition
splitting embryos at early stages of cell growth to get two identical embryos, then keep splitting
Term
No genetic variation
Definition
How cloning affects genetic change
Term
Controlling Sex
Definition
determining sex of a pre-implanted embryo
Term
1. Almost doubles the number of selection candidates, which increases selection intensity
Definition
How controlling sex affects genetic change
Term
1. Accuracy of selection increases (if the correct DNA-phenotype association are known)
2. Can decrease generation interval by limiting the need for progeny testing
Definition
2 ways gene technologies can enhance genetic change
Term
Quantitative Trait Loci (QTL)
Definition
areas of the genome that are associated with traits of interest
Term
Genetic/Genomic Marker
Definition
any gene or DNA sequence used to identify location on a genetic map
Term
Single Nucleotide Polymorphism (SNP)
Definition
a place where we see genetic varience
Term
Genome Wide Association Study (GWAS)
Definition
a study to predict which areas of the genome contribute to variance of a given trait
Term
Statistical Genomics
Definition
performs GWAS to predict which markers are associated with traits of interest and how much of an effect each marker has
Term
Manhattan Plot
Definition
plot of results from a genome scan; shows which genomic regions are significantly associated with traits of interest
Term
Training
Definition
identify markers that are associated with traits of interest and estimate marker effects
Term
Validation
Definition
test markers using a different set of animals to ensure they are truly associated with the trait of interest
Term
Marker Assisted Selection
Definition
use genotype information to aid in making selection decisions
Term
Whole Genome Selection
Definition
allows us to incorporate all known SNP into the genetic evaluation so that markers with small effects are not ignored
Term
Genomic Sequencing
Definition
obtaining the entire genomic sequence from an animal or plant
Term
Imputation of Genotypes
Definition
statistical inference of unknown genotypes
Term
Transfer of Genes
Definition
transferring genes within species or across species
Term
Gene Splicing
Definition
cutting a piece of DNA and inserting it into the embryonic DNA of another species
Term
Transgenic Animals
Definition
animals whose genomes contain foreign genes
Term
Gene Knockout
Definition
genetic technique in which one of an organism's genes is inactivated or deleted
Term
Coancestry
Definition
probability that a randomly drawn gene from animal X is identical by descent with a gene randomly drawn from animal Y
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