Term
|
Definition
General IV anestetic (not common US) that comes as a sodium salt, pH>10.
PRECIPITATES IN ACID ENV.
THROMBOEMBOLIC ARTERIAL COMPLICATIONS
Gaba-A agonist that activates cl-
rapidlly redistributes from brain
prolonged hangover from slow hepatic metabolism (except phenobarbital)
CONTRAINDICATED PORPHRIA
rapid onset, hypotension with reflex tachycardia. Isoelectric EEG. sometimes used as an anticonvulsant |
|
|
Term
| Benzodiazepines (anesthesia) |
|
Definition
not typically from IV but used as a pre-op anxiolytic
LORAZEPAM = RETROGRADE Amnesia long activing by glucuronidation
Midzalam = short active anterograde by microsomal oxidation
Binds gamma subunit GABA-R.
Variable onset by type, mild drop in BP, no change HR/RR
drops CMRO --> iso EEG |
|
|
Term
|
Definition
agent of choice IV anestesia with rapid onset and repid redistribution
EGG YOLK EMULSION MAY GRO BACTERIA
directly activates gaba-r
HAS HIGH PLASMA CLEARANCE --> NO HANGOVER
rapid hepatic met to inactive then excreted kidney
SIGNIFIGANT HYPO-T (V and A) + APNEA
Isoelectric EEG + pain on injection
REDUCES POST OP NAUSEA/VOMITING
(remember drops everything) |
|
|
Term
|
Definition
hemodynamically stabile general anestetic with little analgesia
comes in a PEG mixture
metabolism by PLASMA ESTER HYDROLASE = slight hangover
moderate respiratory depression but NO DELTA BP/HR = HEART PATIENT or BLEEDING
EXCITATORY EEG!!! (avoid seizure ppl)
increase POST OP NAUSEA/VOMIT and
steroid supression of 11-b-hydroxylase |
|
|
Term
|
Definition
rapid dissociative amnesia (not hypnosis)
ANTAGONISM NMDA RECEPTOR
low protein binding and h2o soluble
N-demethylation to active metabolite in LIVER
1. unpleasant nightmares/re-emergence (not as likely children)
2. CMRO2 increasese = CONTRA-INDICATED TUMORS but decreaes seizures
SIGNIFIGANT NYSTAGMUS/SALVATION/LACRIMATION
INCREASES HR/BP/CBF from NorE stimulaton |
|
|
Term
Monitored anestesia care (MAC)
vs
SAC |
|
Definition
| Monitored requires presence of anesthesiologist |
|
|
