Term
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Definition
Activates guanylyl cyclase, leading to an increase in cGMP, which facilitates dephosphorylation of myosin light chains, causing smooth muscle relaxation and vasodilation.
Take breaks from NO at night to prevent tolerance development.
Nitroglycerin is converted to NO inside smooth muscle cell.
Primary effect is venodilation, leading to decreased preload. May also cause orthostatic hypotension and syncope. |
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Term
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Definition
Block L-type Calcium channels, preventing activation of calmodulin, preventing activation of myosin light chain kinase, preventing phosphorylation of myosin light chains.
Decreases peripheral resistance and reduces coronary vasospasm. |
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Term
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Definition
| Ca channel blockers with greater smooth muscle effects than cardiac effects. |
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Term
Nondihydropyridine Ca channel Blockers
(Verapamil, Diltiazem) |
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Definition
| More cardiac action than dihyd. Ca blockers. Cause less reflex tachycardia. |
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Term
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Definition
| Inhibit fatty acid oxidation pathway in myocardium, shifting metabolism toward glucose usage, which requires less oxygen consumption. |
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Term
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Definition
| Originally thought to be a pFOX inhibitor. Now believed to reduce contractility by blockade of late Na current, leading to decreased intracellular Ca. |
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