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any abnormal condition of an animal that causes some dysfunction or affects an organ system or organ function regardless of whether overt sings are present or not |
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signs of disease that are overt |
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Microscopic pathology (histopathology) |
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disease @ the cellular level |
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rapid onset, clinical signs are less that 24-48 hrs |
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clinical signs of a disease persist beyond 2-3 days |
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Infectious causes of disease |
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bacterial fungal viral protozoal |
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arthritis (due to old age) |
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due to trauma (musculosketletal system or nervous system) |
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Cardinal signs of inflammation |
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heat swelling pain loss of function redness |
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Primary cancer vs. secondary |
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primary is just cancer secondary is caused by infectious agents |
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disorder occurs during pregnancy (may be chromosomal but not necessarily) |
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metabolic (homronal or nutritional) nutritional (deficiency or excess) toxicity (ingestion, plants, chems, human error) |
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2 components of immune system |
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WBC travel and kill lymphocytes send message and kill, memory lymphocytes |
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large proteins, attracted to antigens, phagocytosis |
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species resistance breed resistance individual resistance (age, body cond., nutritional/environmental) |
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immunity from an outside source |
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immune system was stimulated to produce antibodies |
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antibodies were obtained from an outside source (oral, injectable, monoclonal) |
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newborn to weanling weanling to 2 yrs. adult cows adult bulls |
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Inherited abnormalities of growth plates hydrocephalus |
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Double Muscling of cattle |
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Inherited disorders (breeds like Charolais, Peidmontese) common difficulties calving |
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Curly Calf Syndrome inherited |
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Neuropathic Hydrocephalus |
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congenital female born twin to male clinical signs small vulva/enlarged clitoris failure to show heat absent or underdeveloped ovaries, uterus |
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abortions(not to term) stillbirths(to term) birth defects -BVD (bovine viral diarrhea septicemia limb deformities nutritional disorders during gestation White muscle disease toxins |
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congenital, nutritional affects cardiac and skeletal muscle causes cardiac arrest (stillbirth) give selenium injections at birth and/or supplement dam during pregnancy |
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contracted tendons possibly due to improper position in uterus medical or surgical treatment |
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Protection against infectious diseases in the newborn calf |
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clean birthing area clean/disinfect navel w/ mild disinfectant adequate colostrum intake |
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vitamins minerals fat(glucose, lactose) carbs antibodies (proteins) |
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concentrated solution of antibodies 1st mammary product after birth passive immunity transfer **make sure baby gets it!!! **plasma expensive and not concentrated |
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what colostrum protects against |
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bacteria virus fungal organisms parasites **vaccinate dam for better immunity |
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Peak absorption of colostrum |
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first 6 hours is best get it in first 24 hrs at least **calf is not yet ruminant, suck reflex leads to esophageal groove to get absorbed w/out hydrochloric acid denaturization |
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length of protection from colostral antibodies |
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variation b/w antibodies some 1 some much much more |
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factors affecting antibody concentration (or colostrum quality) |
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-vaccinate dam 6-8 wks prior to parturition -age of dam -nutritional status of dam -diseased mammary system |
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10% of animal's body weight divided over 24 hr period (1 qt./ 25 lbs) |
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allows for digestion helps prevent scours |
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frozen synthetic replacemnt |
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factors affecting calf infectious diseases |
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environmental contamination colostral absorption dystocia (can increase chance 3X's) |
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prolonged time can lead to hypoxia (dummy calf syndrome) affects calve's nursing ability and colostral absorption |
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infection (viral and/or bacterial) that affects multiple organ systems |
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when do microbes enter newborn? |
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prior to birth post calving |
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post-calving microbe invasion happens how? |
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how do microbes affect newborn? |
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enter blood stream seed in many different organs overwhelm newborn |
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death depends on infectious agent watch for: depression dehydration inability to stand loss of suck reflex fever gums pale diarrhea labored breathing shock seizures |
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fluid therapy (oral or IV) -H20, electrolytes antibiotic therapy -broad spectrum supportive care -warm, dry, clean -nutrition |
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virus bacterial protozoal nutritional |
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bacterial, viral, nutritional intestine fails to absorb fluids increased fluid secretion into intestine combo of both |
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fingerlike projections in lining of intestine that increase absorption area viruses cut off villi regeneration occurs 5-7 days scarring may occur |
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general treatment of calf scours |
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vaccination (if viral) fluids- oral or IV nutrional intake (electrolytes [sodium, chloride], potassium, protein) TLC antibiotics (if bacterial, in appropriate location, can combat secondary bacterial infection) |
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viral causes of calf scours |
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rotavirus (vaccinate dam, profuse watery and/or bloody diarrhea, affects w/in first 24 hrs.) coronavirus (vaccinate dam,profuse watery stool, not as fatal as rota, affects calves over 5 days of age) BVD (bovine viral diarrhea) high mortality, vaccinate female prior to breeding |
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bacterial causes for calf scours |
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E.Coli (#1 cause of calf scours, many different strains, some more pathenogenic than others...scours, progressive dehydration, death may occur in hours in severe cases...vaccinate dam during pregnancy) Salmonella (profuse bloody diarrhea, sloughing of intestine, severe depression and dehydration, may come from carrier animals) Enterotoxemia (clostridial perfingens, acute bloody diarrhea and death, vaccinate dam) |
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parasitic causes for calf scours |
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coccidiosis (affects calves older that three weeks) diagnose by fecal exam blood in stool treat w/ sulfa drugs, cord, fluids, tlc, clean environment |
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erratic nursing patterns white/pasty/rank diarrhea usually self-limiting make sure calf nurses regularly |
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