Term
|
Definition
- fluoxetine
- sertraline
- paroxetine
- fluvoxamine
- citalopram
- escitalopram
|
|
|
Term
| SSRI's MOA & Side Effects |
|
Definition
- Inhibition of 5-HT reuptake
- Inhibition of NE & DA reuptake
- Blocaked of M1 muscarinic-cholinergic receptors
- Bind at 5-HT2c (agonist) and sigma receptors
Side Effects:
- Nausea
- Sexual difficulties
- Fatigue
- Insomnia
- Dizziness
- Weight Gain
- Headache |
|
|
Term
| List of Serotonin and NE Reuptake Inhibitors (SNRIs) |
|
Definition
- Venlafaxine
- Desvenlafaxine
- Duloxetine
- Adverse effects similar to SSRI's
- Sustained increase in diastolic BP @ higher doses, requires BP monitoring
- May require titration to reduce nausea |
|
|
Term
|
Definition
Noradrenergic & Specific Serotonergic Antidepressants (NaSSAs)
- antagonizes alpha-2, 5-HT2a, 5-HT2c & 5-HT3 receptors
Side Effects
- Sedation
- Weight Gain |
|
|
Term
|
Definition
NE & DA reuptake Inhibitor (NDRI)
- Adverse Effects:
- agitation, insomnia, weight loss
- lowers seizure threshold
- may worsen or precipitate psychotic symptoms
- Drug interactions
- stimulants
- DA agonists/antagonists
|
|
|
Term
|
Definition
Serotonin Antagonist & Reuptake Inhibitors (SARI's)
- Serotonin (5-HT2a) receptor antagonism & 5-HT reuptake inhibition
Adverse effects:
- sedation & orthostatic hypotension
- priapism (painful erections) from Trazadone
|
|
|
Term
|
Definition
tryptyline or -pramine (doxepin is the only exception)
- Inhibition of 5-HT & NE reuptake
- Blockade of α1, H1 and M1 receptors
Side Effects
- Anticholinergic - dry mouth, blurred vision, urinary retension, constipation
- Antiadrenergic - orthostatic hypotension
- Cardio - tachycardia, conduction changes
- Sedation |
|
|
Term
Phenelzine
Tranylcypromine |
|
Definition
Monoamine Oxidase Inhibitors
Adverse Effects:
- Sedation or activation
- Orthostatic hypotension
Drug Interactions
- Tyramine
- SSRIs
- TCAs |
|
|
