Term
|
Definition
Phenobarbitol
Anticonvulsants.
generalized tonic-clonic seizure.
enhances GABA, depress Ca channel.
drowsiness, induces hepatics. |
|
|
Term
|
Definition
Phenytoin
Anticonvulsants.
generalized and partial seizures.
NOT for absence seizures.
decreases Na, Ca, K flow.
GINGIVAL hyperplasia, Folate, Peripheral neuropathy, masculinization. |
|
|
Term
|
Definition
Carbamazepine
Anticonvulsants.
for partial, generalized tonic-clonic, trigeminal neuralgia.
prolonged recovery of Na channels.
N&V, diplopia, hematologic/thrombocytopenia. |
|
|
Term
|
Definition
Valproate/Divalproex
Anticonvulsants.
can treat ABSENCE.
Na and GABA
weight gain, hair loss, liver |
|
|
Term
|
Definition
Ethosuximide
Anticonvulsants.
Absence Seizures.
Block Ca channel, decreased glucose transport. drowsiness. |
|
|
Term
|
Definition
Benzodiazepines
Anticonvulsants.
diazepam and lorazapam (status, EtOH withdrawl). clonazepam (akinetic, myoclonic, Lennox-Gastaut)
enhanced GABA binding.
abuse potential, tolerance. |
|
|
Term
|
Definition
Felbamate
Anticonvulsants.
adjunct for complex partial, lennox-gastaut.
NMDA antagonist.
aplastic anemia, hepatotoxic.
NOT a first line. |
|
|
Term
|
Definition
Lamotrigine
Anticonvulsants.
used for complex partial.
inhibits Na channels.
Steven's Johnson. |
|
|
Term
|
Definition
Gabapentin
Anticonvulsants.
adjunct for complex partial.
MOA-everything.
also: bipolar, chronic pain, peripheral neuropathy.
eliminated in KIDNEYS. |
|
|
Term
|
Definition
Pregabalin
Anticonvulsants.
adjunct complex partial.
Ca channel.
tx: POSTHERPETIC NEURALGIA. |
|
|
Term
|
Definition
Topiramate
Anticonvulsants.
complex partial, GTCS, Lennox Gastaut.
inhibits Na, enhances GABA.
drink plenty of FLUIDS (kidney stones).
used in migraines |
|
|
Term
|
Definition
Tiagibine
Anticonvulsants.
Adjunct complex-partial.
inhibits GABA reuptake (GAT-1). |
|
|
Term
|
Definition
Levetiracetam
Anticonvulsants.
adjunct complex partial.
binds synaptic vesicular protein SV2A.
Asthenia |
|
|
Term
|
Definition
Zonisamide
Anticonvulsants.
adjunct complex-partial.
inhibits Na and Ca.
kidney stones. |
|
|
Term
|
Definition
Lacosamide
Anticonvulsants.
adjunct complex-partial.
enhances slow activation Na channels.
euphoria (controlled substance).
cardiac s/e. |
|
|
Term
|
Definition
Rufinamide
Anticonvulsants.
adjunct for lennox gastaut in patients >4 yo. prolonged inactivation Na channel
cardiac s/e |
|
|
