Term
REVIEW
What cells are involved in the innate immune response? |
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Definition
Mcrophages
Neutrophils
DC
NK cells |
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Term
REVIEW
What is the role of complement? |
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Definition
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Term
REVIEW
What cytokines (and functions) are involved in the innate response? |
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Definition
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Term
REVIEW
What are the effector mechanisms against a) extracellular and b) intracellular pathogens? |
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Definition
a) complement
b) dendritic then later NK cells |
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Term
| Difference between innate and adaptive immune response? |
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Definition
| Adaptive is driven by antigen-specific receptors |
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Term
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Definition
| Describes the properties of antibodies and TCR that interact selectively with only one type or a few types of antigens (epitopes). |
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Term
| Why are B cells flexible? |
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Definition
| Hinges on a disulfide bond |
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Term
| B cell start off as ___ ____ proteins. T cells, however, remain on the ____. |
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Definition
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Term
| Antibody structure consists of 4 proteins which are: |
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Definition
Pair of identical 2 heavy chains
2 light chains |
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Term
| T cell receptor structure are made up of: |
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Definition
| same size: alpha and beta |
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Term
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Definition
| Protein on the antigen that binds to antigen binding site |
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Term
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Definition
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Term
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Definition
| ONE THING (ONLY peptides that are tightly associated w/ other molecules aka - ACCESSORY MOLECULES) |
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Term
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Definition
Major Histocompatibility Complex MHC)
Human Leukocyte Antigen (HLA) |
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Term
| Two different types of T cells that are needed to eliminate pathogens: |
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Definition
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Term
| Pathogens that live INSIDE cells get represented by: |
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Definition
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Term
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Definition
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Term
| Pathogens that live OUTSIDE the cell get represented by: |
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Definition
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Term
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Definition
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Term
| CD8 binding to HLA class I induces what to the cell? |
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Definition
| APOPTOSIS - gets rid of virus |
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Term
| Does apoptosis occur in the cell when CD4 binds to HLA class II? |
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Definition
| NO- need to alert the rest of the body |
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Term
| A B cell receptor looks like which Class protein? |
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Definition
(Mnemonic::: B1T2)
class I (bc has heavy and light chains) |
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Term
| A T cell receptor looks like which Class protein? |
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Definition
(Mnemonic::: B1T2)
CLASS II because has 2 similar size chains (alpha and beta) |
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Term
Extracellular and Intracellular Pathogens must be treated differently in the cell:
Where do extracellular pathogens end up in the cell? |
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Definition
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Term
Extracellular and Intracellular Pathogens must be treated differently in the cell:
Where do intracellular pathogens end up in the cell? |
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Definition
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Term
| Where do HLA class I and II get synthesize inside the cell? |
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Definition
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Term
| What does TAP do in the ER? |
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Definition
| Membrane bound protein that transports peptide fragments from cytosol into ER |
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Term
| What is the purpose of changing the proteosome subunits and increasing the production of HLA class I? |
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Definition
| Make virally infected cells better targets for CD8 T cell killing |
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Term
| How to maximize peptide presentation? |
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Definition
| MHC molecules are polygenic. MHC molecules are polymorphic. NOTE: for T cell, it's gene rearrangement |
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Term
| The ability of HLA molecules to present repertoire of peptides: |
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Definition
polygeneism
Anchor residues |
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Term
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Definition
| The AA (of the antigen peptide) that the HLA molecule attach to |
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