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Antihypertensives
antihypertensives, antiarrhythmics, atihyperlipidemics
51
Pharmacology
Graduate
02/21/2010

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Cards

Term
WHAT DIURETICS CAN BE USED AS ANTIHYPERTENSIVES?
Definition
HYDROCHLOROTHIAZIDE - THIAZIDE DIURETIC
AMELIORIDE - K SPARING
ATENOLOL - BETA BLOCKER
DOXAZOSIN - BB
CLONIDINE - ALPHA2 AGONIST
ENALAPRIL - ACE INHIBITOR
LOSARTAN - ANG RECEPTOR INHIBITOR
AMLODIPINE - CCB - VD
HYDRALAZINE - NITRATE - VD
FENOLDOPAM - DOPAMINE AGONIST
Term
WHAT BP IS CONSIDERED HTN?
Definition
BP > 140/90
Term
STAGE 1 HTN
Definition
140/90 TO 159/99
Term
STAGE 2 HTN
Definition
> 160/100
Term
HOW IS BLOOD PRESSURE REGULATED?
Definition
BARORECEPTORS + SNS FAST
RENIN-ANG-ALDO - HORMONAL SLOW
Term
WHATS THE ACTION OF ANTIHYPERTENSIVES?
Definition
DECREASE EXCESSIVE SNS ACTIVITY
MODIFY RENAL Fx TO COUNTERACT HTN
Term
REFLEX RESPONSE DUE TO LOW BP?
Definition
INCREASE SNS ->+B1 HEART, +A1 VSM -> INCREASE CO AND RESISTANCE
+ R-A-S ->INCREASE RENIN->ALDO->INCREASE BV
Term
DIURETICS USED FOR HTN?
Definition
THIAZIDES
K SPARING - AMELIORIDE
Term
THIAZIDE EFFECTS ON SERUM?
Definition
DECREASE K
INCREASE CHOL. - LDL - TG
Term
LOOP DIURETICS ON SERUM?
Definition
DECREASE K
INCREASE CHOL, LDL, TG
Term
WHICH DIURETICS INCREASE K?
Definition
K SPARING DIURETICS - AMELIORIDE
SPIRONOLACTONE
Term
WHICH DIURETICS INCREASE LDL, CHO, TG BUT DECREASE K?
Definition
THIAZIDES
LOOP DIURETICS
Term
THIAZIDES COMMON ADVERSE AFFECTS?
Definition
HYPOKALEMIA
HYPERLIPIDEMIA
HYPERURECEMIA
HYPERGLYCEMIA
HYPONATREMIA
Term
K SPARING DIURETICS COMMON ADVERSE EFFECTS?
Definition
HYPERKALEMIA
GYNECOMASTIA (SPIRONOLACTONE)
Term
ATENOLOL (TENORMIN) MOA?
Definition
B1 ANTAGONIST
Term
PROPRANOLOL (INDERALL) MOA?
Definition
NON SELECTIVE BETA BLOCKER
Term
CLONIDINE MOA?
Definition
CENTRAL A2 AGONIST
CAN CROSS BBB
Term
DOXAZOSIN (CARDURA) MOA?
Definition
A1 ANTAGONIST
ALSO INDICATED FOR BPH
Term
SYMPATHOLYTICS MOA AGAINST HTN?
Definition
BB - DECREASE HR, CONTRACTILITY, RENIN
A BLOCKERS - BLOCK INCREASE IN PERIPHERAL VASCULAR RESISTANCE
A2 AGONIST - DECREASE SNS OUTFLOW (BRAIN)
Term
ALPHA BLOCKERS ON SERUM?
Definition
DECREASE CHOL, LDL, TG SLIGHTLY
NO CHANGE IN SERUM K
Term
BETA BLOCKERS ON SERUM?
Definition
SMALL INCREASE TO NONE IN
K, LDL, CHOL, TG
HDL VARIABLE
Term
A2 AGONISTS ON SERUM?
Definition
NO CHANGE
Term
ALPHA BLOCKERS ADVERSE EFFECTS?
Definition
FIRST DOSE PHENOMENON (SYNCOPE)
DIZZINESS
ORTHOSTATIC HYPOTENSION
FLUID RETENTION
INTERACTION WITH BB- INCREASE HYPOTENSION
Term
BETA BLOCKERS ADVERSE EFFECTS?
Definition
BRONCHOCONSTRICTION DO NOT USE WITH ASTHMA
IMPAIRED GLYCOGENOLYSIS
BRADYCARDIA
DEPRESSION
FATIGUE
NIGHTMARES
Term
A2 AGONISTS ADVERSE EFFECTS?
Definition
REBOUND HTN
DRY MOUTH
FATIGUE
SEDATION
SAFE FOR PREGNANCY
Term
HTN TREATMENT DURING PREGNANCY?
Definition
CLONIDINE - A2 AGONIST
Term
THE 'PRILS' ARE...
Definition
ACE INHIBITORS

ENALAPRIL (VASOTEC)
Term
THE 'SARTANS' ARE...
Definition
ANGIOTENSIN RECEPTOR BLOCKERS

LOSARTAN (COZAAR)
Term
ANGIOTENSIN INHIBITORS ON SERUM?
Definition
INCREASE K
INCREASE K
INCREASE K :-)
Term
ACE INHIBITORS ADVERSE EFFECTS?
Definition
RENAL FAILURE COUGH
HYPERKALEMIA
angioedema
loss of taste
neutropenia
teratogenic
Term
ACE INHIBITORS DRUG INTERACTIONS?
Definition
INHIBITED BY NSAIDS
INCREASE IN LITHIUM
HYPERKALEMIC EFFECT
Term
ANGIOTENSIN RECEPTOR BLOCKER ADVERSE EFFECTS?
Definition
HYPERKALEMIA
RENAL FAILURE
TERATOGENIC
Term
ANGIOTENSIN RECEPTOR BLOCKER DRUG INTERACTIONS?
Definition
P450 EFFECTS: METABOLISM INHIBITED BY CIMETIDINE
AND ENHANCED BY BARBITUATES
Term
ANGIOTENSIN RECEPTOR BLOCKER MOA?
Definition
BLOCK ADRENAL CORTEX RECEPTORS SO NO ALDOSTERONE
BLOCK RECEPTORS ON ARTERIOLES SO NO VASOCONSTRICTION
Term
ACE INHIBITORS MOA?
Definition
BLOCK ACE SO ANGIOTENSIN I CANNOT BE CONVERTED TO ANGIOTENSIN II
Term
VASODILATORS ON HTN?
EFFECTS ON SERUM?
Definition
AMLODIPINE (NORVASC) - CCB
asthmatics
african heritage
HYDRALAZINE - NITRATE
ALSO MINOXIDIL
SERUM EFFECTS ARE MINIMAL
Term
AMLODIPINE (NORVASC) ADVERSE EFFECTS?
DURG INTERACTIONS?
Definition
DIZZINESS
EDEMA
GINGIVAL HYPERPLASIA
HEADACHES
TACHYCARDIA

P450 EFFECTS: METABOLISM INHIBITED BY CIMETIDINE
Term
HYDRALAZINE ADVERSE EFFECTS?
DRUG INTERACTIONS?
Definition
ANGINA
DIZZINESS
FLUID RETENTION
HEADACHES
LUPUS-LIKE SYNDROME
TACHY
HYPERTRICHOSIS W/ MINOXIDIL

INHIBITED BY NSAIDS
Term
NSAIDS INHIBIT?
Definition
ACE INHIBITORS
BETA BLOCKERS
HYDRALAZINE
Term
CIMETIDINE INHIBITS METABOLISM OF WHICH ANTIHYPERTENSIVES?
Definition
AMLODIPINE (NORVASC) - VASODILATOR- CCB
LOSARTAN (COZAAR) - ANG RECEPTOR BLOCKER
Term
Tx OF HTN WITH ANGINA?
Definition
BETA BLOCKERS
CALCIUM CHANNEL BLOCKERS - CCB
Term
Tx OF HTN WITH DIABETES?
Definition
ACE INHIBITORS
CCB
Term
TX OF HTN WITH HYPERLIPIDEMIA?
Definition
ACE INHIBITORS
CCB
Term
TX OF HTN WITH CHF?
Definition
DIURETICS
ACE INHIBITORS
***AVOID VERAPAMIL****
Term
VERAPAMIL SHOULD BE AVOIDED IN PATIENTS SUFFERING FROM WHICH 2 CONCOMITANT DISEASES?
Definition
CONGESTIVE HEART FAILURE
HTN
Term
TX OF HTN WITH PREVIOUS MI?
Definition
BETA BLOCKERS
ACE INHIBITORS
Term
TX OF HTN WITH ASTHMA OR COPD?
Definition
DIURETICS
CCB
Term
GIVE CCB FOR?
Definition

EVERYTHING BUT HTN WITH CHF!!!!

HTN WITH ANGINA, HYPERLIP, DM, CHRONIC RENAL DISEASE, ASTHMA

Term
GIVE ACE INHIBITORS TO PTS WITH HTN AND?
Definition
DM
HYPERLIP
CHF
MI
Term
GIVE BETA BLOCKERS TO PTS WITH HTN AND ?
Definition
ANGINA
MI ( PREVIOUS)
Term
GIVE DIURETICS TO PTS WITH HTN AND?
Definition
CHF
CRD
COPD
ASTHMA
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