Term
| best treatment of Toxoplasmosis |
|
Definition
|
|
Term
| Pyrimethamine and sulfonamide |
|
Definition
|
|
Term
| May want to administer Leucovorin with this to protect against folate deficiency |
|
Definition
|
|
Term
synthetic hydroxy-naphthoquinone.
Highly lipophilic.
Resembles ubiquinone.
Inhibits mitochondrial ETC and related processes |
|
Definition
|
|
Term
Used in toxoplasmosis and AIDS patients to treat P. carinii pneumonia.
Alternate drugs: Spiramycin, Clindamycin |
|
Definition
|
|
Term
| Antimycobacterial drug, but also used for fungal/protozoal pneumocystosis |
|
Definition
|
|
Term
| Eflornithine IV used to treat |
|
Definition
|
|
Term
Unknown mechanism possibly polymerase or oxidative phosphorylation?
Parenteral administration for PCP
Renally cleared
half life varies |
|
Definition
|
|
Term
| probably number one treatment for PCP |
|
Definition
|
|
Term
| slow acting for eythrocytic cycle: |
|
Definition
| Proguanil and pyrimethamine (inhibits plasmodial DHFR) |
|
|
Term
| Exoerythrocytic stage DOC |
|
Definition
| Chloroguanide (Proguanil) |
|
|
Term
Tissue schizonticides - prevent relapse:
mechanism: latent exo-erythrocytic form
Drug |
|
Definition
|
|
Term
Gametocides - prevents infection in mosquito
destroys gametocytes in human blood and prevents vector transmission
DOC for P. falciparium |
|
Definition
|
|
Term
Gametocides - prevents infection in mosquito
destroys gametocytes in human blood and prevents vector transmission
DOC for species besides falciparium |
|
Definition
|
|
Term
| Possibly inhibits plasmodial heme polymerase? Intercalation w/ parasitic dna |
|
Definition
|
|
Term
Proper concentrations safe drug.
High dose = rare:
retinal damage
ototoxicity
visual disturbances |
|
Definition
|
|
Term
Used for chloroquine resistant plasmodium inections (P. Falci)
Damages parasite membranes
CDC limits use |
|
Definition
|
|
Term
| Its oxidants are schizonticides that inhibit plasmodial DNA replication |
|
Definition
|
|
Term
| Only drug used clinically to eradicate latent tissue and hepatic forms responsible for relapses (vivax, ovale) |
|
Definition
|
|
Term
Reserve drug. For resistant strains.
Useful in asexual erythrocytic forms , not active vs. exoerythrocytic forms |
|
Definition
|
|
Term
| blood schizonticide(erythrocytic) for chloroquine resistant Falciparium |
|
Definition
|
|
Term
| Inhibits DHFR. Use with chloroquine in prophalaxis |
|
Definition
|
|
Term
| Available in US only in combo with Atovaquone for malaria |
|
Definition
|
|
Term
| Combo of Atovaquone and Proguanil |
|
Definition
|
|
Term
| Considered best drug for Malaria |
|
Definition
|
|
Term
| administered orally as tablet and should be with food or milk |
|
Definition
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