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apples
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112
Pharmacology
Professional
04/03/2012

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Term
"caines" with one "i"s
cocaine, benzocaine, procaine, propoxycaine, tetracaine
Definition
ESTER local anesthetics.
Term
"caines" with two "i"s
lidocaine, mepivacaine, bupivacaine, ropivacaine, etidocaine, prilocaine
Definition
Amide Local Anesthetics
Term
norepinephrine, epinephrine, phenylephrine, felypressin
Definition
vasoconstrictors adjunct to local anesthetics to prolong duration
Term
Surface anesthesia
Definition
Most superficial afferent neurons block
Term
Infiltration anesthesia
Definition
in the muscle, blocks more neurons thatn surface
Term
Conduction anesthesia
Definition
Blocks nerve trunks and not just individual nerves
Term
Spinal anesthesia
Definition
self explanatory, blocks everything below where the anesthesia is injected in the spine
Term
Type A Nerve fiber
Type alpha Nerve Fiber
Definition
Motor, proprioception. Biggest diameter >12. Least sensitive to block, fastest conduction.
Term
Type A NErve fiber
Beta
Definition
Touch and pressure, 5-12 diameter
Term
Type A nerve fiber
gamma
Definition
Muscle Spindles 3-6 micrometer diameter
Term
Type A Nerve fiber
Delta
Definition
Pain, Temperature 1-4 diameter. Slowest conduction but highest sensitivity AMONG TYPE A NERVE FIBERS
Term
Type B Nerve Fiber
Definition
Prganglion, sympathetic. Lower than 3 diameter.
Term
Type C; Dorsal Root sympathetic
Definition
Pain (0.4-1.2), Postganglionic sympathetic. (0.3-1.3
Term
Methylparaben
Definition
Used as a preservative for local anesthetics. Reason why some anesthetics caused allergic reactions
Term
Atypical Pseudocholinesterase
Definition
A genetic variation of an enzyme
Term
Methemoglobinemia
Definition
Prilocaine, lidocaine, benzocaine metabolites can cause this
Term
General Anesthesia Induction
Definition
Time it takes to achieve surgical anesthesia
Term
General Anesthesia Maintenance
Definition
Keeping patient at stable state of surgical anesthesia
Term
General Anesthesia Emergence
Definition
Recovery from general anesthesia
Term
Stage Analgesia
Definition
Might still feel pain but brain cant tell wherer its coming from. Patient awake and consicous
Term
Behavioral Excitation
Definition
Inhibits inhibitory mechanism first causing respiration, BP, HR to increase and muscles to twitch
Term
Surgical Anesthesia
Definition
The stage where you want to maintain the patient
Term
Medullary paralysis
Definition
Too much anesthetic can cause death
Term
MAC or minimum alveolar concentratoin
Definition
Amount of gas that knocks out 50% of the patient
Term
Second gas effect
Definition
Combination of drag that adds up to full mac value
Term
Nitrous Oxide
Definition
General anestehtic inhalation agents
Term
Halothane
Definition
Fluorinated hydrocarbon as general anesthetic inhalation agent
Term
Isoflurane
Definition
Fluorinated hydrocarbon as general anesthetic inhalation agent
Term
sevoflurane
Definition
Fluorinated hydrocarbon as general anesthetic inhalation agent
Term
Dantrolene IV
Definition
Only effective drug to interfere with excitation contraction complement
Term
Thiopental (pentothal)
Definition
IV general anesthetic agent that enhance inhibitory GABA neurotransmission
 no analgesia or skeletal muscle relaxation (combine opioid)
Term
Propofol (diprivan)
Definition
IV general anesthetic agent that enhance inhibitory GABA neurotransmission
 no analgesia or skeletal muscle relaxation (combine opioid)
Term
Etomidate (amidate)
Definition
IV general anesthetic agent that enhance inhibitory GABA neurotransmission
 no analgesia or skeletal muscle relaxation (combine opioid)
Term
Midazolam (versed)
Definition
IV general anesthetic agent that enhance inhibitory GABA neurotransmission. This is a benzodiazepine
 no analgesia or skeletal muscle relaxation (combine opioid)
Term
Ketamine (ketalar)
Definition
IV general anesthetic agent that inhibit excitatory NMDA neurotransmission. Dissociate anesthsia with analgesia
Term
droperidol/fentanyl (Innovar®)
Definition
IV general anesthetic agent - neuroleptanalgesia (neuroleptic and analgesic drug)
Term
Substance P
Definition
Neurotransmitter released from pain signals
Term
Naloxone (narcan)
Definition
Antidotal Therapy for morphine toxicity (short duration)
Term
Naltrexone (Trexan)
Definition
Antidotal Therapy for morphine toxicity (long acting)
Term
Morphine, Codeine
Definition
Phenanthrenes, Opium alkaloids
Term
Hydromorphone/codone: oxymorphone/codone - Diacetylmrphine
Definition
Semisynthetic opiate drugs
Term
Methadone
Definition
Phenylptylamines. 3x morphine potency
Term
Levomethadyl
Definition
Phenylptylamines - treatment of addiction
Term
Meperidine
Definition
phenylpiperidines: 1/8 x morphine potency
Term
fentanyl
Definition
phenylpiperidines: 80x morphine potency
Term
Alfentanil
Definition
phenylpiperidines: 10x morphine potencyt
Term
sufentanil
Definition
phenylpiperidinesL 500x morphine potnecy
Term
Carfentanil
Definition
phenylpiperidines 8000x morphine opotency - for bears and big animals
Term
Enkephalins
Definition
endogenous opioid peptides - brain and spinal cord neurotransmitter; also releaed from adrenal medulla as a hormione. mu and delta receptors
Term
Methinoine
Definition
an enkephalin
Term
endorphins
Definition
endogenous opioid peptides, brain neurotransmitter and pituitary hormone. Mu and epsalon.
Term
Dynorphins
Definition
endogenous opioid peptides . Brain and spinal cord neurtransmitter. exclusively kappa
Term
Endomorphins
Definition
Brain neurotransmitter. Mu
Term
mu opiate receptors
Definition
for morphine and most clinical narcotic analgesics; thought to produce strongest analgesia
Term
kappa opiate receptors
Definition
for mixed agonist-antagonist
Term
delta opiate receptors
Definition
agonist under development. better for neuropathetic pain. and less addiction etc.
Term
Dezocine
Definition
Partial agonist - mu
Term
Pentazocine (talwin)
Definition
Mixed antagonist(mu) - agonist(kappa).
Term
nalbuphine
Definition
Mixed antagonist(mu) - agonist(kappa).
Term
butorphanol
Definition
Mixed antagonist(mu) - agonist(kappa).
Term
Methysergide
Definition
Ergot derived prophylactic agent for migraines. prevent initial 5HT induced vasoconstriction
Term
ergotamine
Definition
nonspecific vascular smooth muscle stimulation to reverse reactive vasodilation
Term
Sumatriptan, rizatriptan, eletriptan
Definition
Stimulation of 5HT to promote vasoconstriction
Term
Ascending Reticular activation system (ARAS) or reticular formation
Definition
sends message to cortex from peripheral afferent neurons
Term
Thiopental
Definition
A thiobarbiturate. Ultra short acting barbiturate sedative
Term
Secobarbital
Definition
short-to intermidiate acting oxybarbiturate
Term
Pentobarbital
Definition
short-to intermidiate acting oxybarbiturate
Term
Amobarbital
Definition
short-to intermidiate acting oxybarbiturate
Term
Phenobarbital
Definition
long-acting (oxy)barbiturate
Term
Primidone
Definition
long-acting (oxy)barbiturate : prodrug of phenobarbital
Term
Ultrashort acting barbiturates
Definition
Useful for IV general anesthetics
Term
short-tointermediat acting barbiturates
Definition
Sedative-hypnotics
Term
long-acting anticonvulsants barbiturates
Definition
anticonvulsants
Term
acute intermittent porphyria
Definition
Only absolute contraindication of barbiturates. Porphyrins, which are needed for hemoglobin are created in excess and stored in tissues.
Term
flumazenil
Definition
antagonizes benzodiazepines and imidazopyridines
Term
ramelteon
Definition
agonist at melatonin 1 and 2. no direct effect on gaba. only non scheduled rx to treat insomnia
Term
Diazepam
Definition
Centrally-Acting Muscle Rexalants -drugs that likely facilitate inhibitory GABAA neurotransmission
Term
carisoprodol
Definition
Centrally-Acting Muscle Rexalants -drugs that likely facilitate inhibitory GABAA neurotransmission
Term
cyclobenzaprine
Definition
Centrally-Acting Muscle Rexalants -drugs that likely facilitate inhibitory GABAA neurotransmission
Term
orphenadrine
Definition
Centrally-Acting Muscle Rexalants -drugs that likely facilitate inhibitory GABAA neurotransmission
Term
baclofen
Definition
Centrally-Acting Muscle Rexalants -drugs that stimulate inhibitory GABAB receptors
Term
tizanadine
Definition
Centrally-Acting Muscle Rexalants - drugs that facilitate inhibitory 2 adrenergic neurotransmission
Term
dantrolene
Definition
Centrally-Acting Muscle Rexalants peripherally-acting muscle relaxant
competitive antagonism of ryanodine receptor to interfere with calcium release and excitation-contraction coupling (ECC) in skeletal muscle
Term
Rate limiting step of ethanol metabolism
Definition
Alcohol dehydrogenase
Term
ADH2*2
Definition
3xnormal rate of EtOH to acetaldehyde. 80% in asians
Term
ALDH*2
Definition
near inactive form or acetaldehyde dehydrogenase. 60% of asians
Term
disulfiram (Antabuse)
Definition
acetaldehyde dehydrogenase inhibitor. aversion therapy.
Term
Greseofulvin, metronidazole, sulfonylureas.
Definition
has signifianct disulfiram like action
Term
BAL0.40-0.50%
Definition
Circulatory, respiratory depression, coma, death
Term
BAL .30%
Definition
Stupor, confused, unable to stay awake
Term
BAL .20%
Definition
Depressed sensory and motor capability, difficulty staying awake, really slurred speech, double vision
Term
BAL .15%
Definition
Impairment of balance, movement, judgment and perception; blurred vision; ataxia
Term
BAL .10%
Definition
Slow reaction time, impaired motor function, slurred speech
Term
BAL .05%
Definition
Lowered alertness, feeling of well-being
Term
BAL .03%
Definition
Relaxation, happy, mild motor impairment
Term
Absence (petit mal)
Definition
consciousness impaired and unresponsive
Term
tonic-clinc (grand mal)
Definition
most common type of seizure. consciousness impaired; initial contraction of muscles (tonic phase) followed by rhythmic contractions (clonic phase)
Term
Myoclonic
Definition
Sudden brief herky jerky movements ofm uscles. no paralysis, no loss of awareness or consciousness.
Term
Atonic.
Definition
Lose all muscle tone and just collapse. theres a disturbance in cosciousness as well.
Term
Phenytoin
Definition
Treatment of psychomotor and tonic-clonic epilepsies
Term
Phenobarbital
Definition
Treatment of psychomotor epilepsy
Term
Primidone
Definition
Pro drug turns into pehnobarbital and phenlethylmalonamide. treatment of psychomotor epilepsy and psychomotor and tonic-clonic epilepsies
Term
Clonazepam
Definition
treatment of absence and myoclonic epilepsies
Term
diazepam
Definition
treatment of status epilepticus
Term
carbamazepine
Definition
Treatment of psychomotor and tonic-clinc epilepsies. treatment of trigeminal and facial neuralgias
Term
Valproic acid (depakote)
Definition
Treatment of psychomotor, tonic-clonic absence of mycolonic epilepsies
Term
Ethosuximide, Trimethadione
Definition
Treatment of petitmal epilepsy
Term
Gabapentin
Definition
Centrally acting GABA agonist
Term
Felbamate
Definition
Positive modulateor of GABA receptors
Term
Topiramate
Definition
Inhibitor of GABA reuptake
Term
Lamotrigine
Definition
NA channel blocker but may also block voltage-activated Ca++
Term
Levetiracetam
Definition
Inhibit spread of electrical activity by unknown mechanism
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