Term
|
Definition
| restricted flow thry pulmonary circulation |
|
|
Term
PAH ultimately leads to
what is the mortality in 1 year |
|
Definition
|
|
Term
| what is the test they do for PAH? |
|
Definition
|
|
Term
| genetic risk factors for PAH-2 |
|
Definition
ALK1 mutations
CPS polymorph |
|
|
Term
|
Definition
|
|
Term
| what are the 4 factros invovled in etiology of PAH |
|
Definition
vasoconstrict
thrombosis
proliferation
inflammation |
|
|
Term
|
Definition
SOB
decreased 6 min walking
elevated BNP |
|
|
Term
| what is goal in meters for the 6 min walk tesT? |
|
Definition
|
|
Term
WHO classificaitons of PAH:
no symtpoms with normal activies |
|
Definition
|
|
Term
WHO classificaitons of PAH:
symtpoms with strenous activiy w/ slight limiation |
|
Definition
|
|
Term
WHO classificaitons of PAH:
symtpoms with strenous activity w/ severe limitation |
|
Definition
|
|
Term
WHO classificaitons of PAH:
symptoms at rest |
|
Definition
|
|
Term
|
Definition
symtpoms
invasive monitoirng (RHC)/swanz Ganz |
|
|
Term
| right heart catheratization has what things on it |
|
Definition
|
|
Term
| indications for using Swanz Ganz-3 |
|
Definition
cardio/pulm instable
shock
fluids |
|
|
Term
|
Definition
infection
arrythmia
thrombus
hemorrhage
pneuothroax
embolus |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| pressure right atrium has to overcome |
|
|
Term
|
Definition
| left atrial pressur from blaoon |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| is PAH when pulmonary vasc resistance is elevated or decreased |
|
Definition
|
|
Term
| if PAH pt is positive for vasoreactive testing what is teatment? |
|
Definition
|
|
Term
| if pt doesnt respond to vasoreactive test and is low risk what is treatment-2 |
|
Definition
|
|
Term
| if pt doesnt respond to vasoreactive test and is high risk what is treatment |
|
Definition
|
|
Term
if a pt has idiopathic PAH what med is given?
what is the goal? |
|
Definition
|
|
Term
| what meds are given for symtpom managment of RV overload? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| what med prevent proliferation and vasoconstriciton |
|
Definition
| endothelin recpt antagonists |
|
|
Term
| what meds prevent vasodilation and apoptosis-3 |
|
Definition
prostanoids
inhaled PO
PDEi |
|
|
Term
| what test is performed for all PAH cadnidates for long term therapy |
|
Definition
|
|
Term
a positive response for the vasodilatory test is reduction of mPAP to less than _ w/o a decrease in-
or
-% decrease in PAP and PVR |
|
Definition
40; cardiac output
PAP; PVR |
|
|
Term
|
Definition
nifedipeine XL
diltiazem
amlodipine |
|
|
Term
|
Definition
| negative ionotropic effects |
|
|
Term
ET recpt antag causes-
bc ET1- _ causes vasoconstriciton |
|
Definition
|
|
Term
| *ET recpt anatg are used if CCB not indicated |
|
Definition
|
|
Term
| what do ET recpt antag do?-3 |
|
Definition
decrease mPAP
imrpove CI
imrpove WHO class |
|
|
Term
what are the ET1 A/B anatagonist
how often dosed |
|
Definition
|
|
Term
what is the ET1-A anatagonist
dosing? |
|
Definition
|
|
Term
| what are the black box warnings for ET recpt-2 |
|
Definition
|
|
Term
| ET recpt antag interact with CYP* |
|
Definition
|
|
Term
| why are PDE-5 inhibitors useful? |
|
Definition
| increase vasodilatory response to NO |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| PDE5 inhibitors do what for PAH-4 |
|
Definition
increase 6 min walking
increase CI
imrpove WHO class |
|
|
Term
| why are protacyclin analogs useful? |
|
Definition
| bc in PAH protacyclins are reduced |
|
|
Term
| what is MOA of prostacyclins? |
|
Definition
| vasodilation of pulm and smooth muscles |
|
|
Term
| what are the effects of prostacyclins-3 |
|
Definition
imrpove 6 min walk
imrpove survival by 5 yrs
increase CI |
|
|
Term
| what are the prostacyclins-3 |
|
Definition
epoprostenol
treprostinil
iloprost |
|
|
Term
| what is cont IV dose of flolan |
|
Definition
|
|
Term
| which drug needs to be kept on ice at all times? |
|
Definition
|
|
Term
| what is the half lfie of flolan? |
|
Definition
|
|
Term
| clinical pearls of flolan? |
|
Definition
cant disct!
must have dedicated line
cant admin with other meds |
|
|
Term
|
Definition
|
|
Term
for flolan calc:
come in:
dose:
pump: |
|
Definition
|
|
Term
| what is the dose for remodulin: |
|
Definition
|
|
Term
| what is the 1/2 life of remodulin |
|
Definition
|
|
Term
| IV remodulin has increased risk of- |
|
Definition
|
|
Term
| ADEs of remodulin are same as |
|
Definition
|
|
Term
| whihc med is an inhaled nebulizer |
|
Definition
|
|
Term
|
Definition
| has to be taken 6-9 times daily |
|
|
Term
| look at slide 30 right before to see the combo therapies fro PAH |
|
Definition
|
|
