Term
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Definition
↓↓↓ HR,CO, BP (causes vasodialation bc of activation of muscarinic receptors)
↑↑↑ Salivary Secretion, Intestinal Motility, Bladder Motility and Urinary Expulsion
-Miosis
(has no therapeutic use) |
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Term
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Definition
-stimulates muscarinic receptors, causing ↑ intestinal motility, and detrusor muscle stimulation in bladder.
Therapeutic applications:
1) atonic bladder stimulation (post-op, post-partum)
2) treatment of neurogenic atony and urinary retention
Adverse Effects:
genaralized cholinergic stimulation (hypotension, increased salivation, bronchospasm, etc.) |
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Term
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Definition
-rarely used therapeutically
--> except in eye as a miotic agent to treat glaucoma (↓ I.O pressure) |
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Term
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Definition
- exhibits muscarinic activity
- produces rapid miosis and ciliary muscle contraction
Therapeutic Effects:
- glaucoma treatment
- drug of choice in emergency I.O pressure lowering
Adverse Effects:
(most potent secretion stimulator)
generalized cholinergic stimulation |
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Term
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Definition
-short-acting AchE inhibitor
-used in diagnosing myasthenia gravis |
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Term
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Definition
-ANS muscarinic and nicotinic receptor stimulant
-↑↑↑ intestinal and bladder motility
-opthalmic agent in eye, causing miosis and lowering of I.O. pressure
-used for glaucoma treatment and anticholinergic drug overdose (as an antidote) |
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Term
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Definition
-effect on skeletal muscle greater than physostigmine
-stimulate GI and bladder
-tubocurarine antidote
-myasthenia gravis treatment
Adverse Effects: General Cholinergic stimulation |
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Term
| PYRIDOSTIGMINE & ABENOMIUM (**) |
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Definition
| -chronic management of myasthenia gravis |
|
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Term
| TACRINE, DONEPEZIL, RIVASTIGMINE, GALANTAMINE (**) |
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Definition
- AchE inhibitors
- alzheimers |
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Term
| ORGANOPHOSPHATE COMPOUNDS (ECHOTHIOPHATE) |
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Definition
- irreversible AchE inhibitors
(insecticides)
-causes skeletal muscle paralysis and generalized cholinergic stimulation
-but used for chronic treatment of glaucoma
atropine-antidote |
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