Term
| What does the extent of receptor response depend on? |
|
Definition
| Extent of response depends on dose of drug and number of receptors stimulated or inhibited |
|
|
Term
| In Somatic Nervous System, what is the neurotransmitter? |
|
Definition
|
|
Term
In Somatic Nervous System, what is the receptor type?
|
|
Definition
|
|
Term
In Sympathetic Nervous System, what is the preganglionic neurotransmitter?
|
|
Definition
|
|
Term
In Sympathetic Nervous System, what is the postganglionic neurotransmitter?
|
|
Definition
|
|
Term
In Parasympathetic Nervous System, what is the preganglionic neurotransmitter?
|
|
Definition
|
|
Term
In Parasympathetic Nervous System, what is the postganglionic neurotransmitter?
|
|
Definition
|
|
Term
In Parasympathetic Nervous System, what is the preganglionic receptor type?
|
|
Definition
|
|
Term
In Parasympathetic Nervous System, what is the postganglionic receptor type?
|
|
Definition
|
|
Term
In Sympathetic Nervous System, what is the preganglionic receptor type?
|
|
Definition
|
|
Term
In Sympathetic Nervous System, what is the postganglionic receptor type?
|
|
Definition
|
|
Term
| How is signal induction terminated between Ach and Cholinergic receptor? |
|
Definition
| destruction by acetylcholinesterase into acetate and choline via binding to anionic and esteratic sites of enzyme |
|
|
Term
| How is muscarinic receptors on all effector organs classified? |
|
Definition
|
|
Term
| How is Nicotinic receptor on all ganglia and adrenal medulla classified as? |
|
Definition
|
|
Term
| How is Nicotinic receptor on skeletal muscles classified as? |
|
Definition
|
|
Term
| What happens when muscarinic receptor is stimulated? |
|
Definition
stimulation of phospholipase C or PLC and increase in IP3, DAG (most)
(blood vessels vasodilatation → NO →c-GMP)
(heart – decrease adenylyl cyclase and cAMP) |
|
|
Term
What happens when nicotinic receptor is stimulated?
|
|
Definition
| Opening of cation channels |
|
|
Term
How is signal transduction terminated between NE and Adrenergic receptor?
|
|
Definition
| active re-uptake back into nerve terminal (membrane, granules) |
|
|
Term
| How is a1 receptor stimulated? |
|
Definition
| stimulation of different phospholipases and increase in IP3, DAG, Ca |
|
|
Term
| How is a2 receptor stimulated? |
|
Definition
| inhibition of adenylyl cyclase and decreases in c-AMP |
|
|
Term
| How is b1 and b2 stimulated? |
|
Definition
| stimulation of adenylyl cyclase and increase in c-AMP |
|
|
Term
| What are the sympathetic receptor of eye? |
|
Definition
|
|
Term
What are the sympathetic receptor of lung?
|
|
Definition
|
|
Term
What are the sympathetic receptor of heart?
|
|
Definition
|
|
Term
What are the sympathetic receptor of blood vessels?
|
|
Definition
|
|
Term
What are the sympathetic receptor of stomach?
|
|
Definition
|
|
Term
What are the sympathetic receptor of intestine?
|
|
Definition
|
|
Term
What are the sympathetic receptor of bladder?
|
|
Definition
|
|
Term
What are the sympathetic receptor of adrenal medulla?
|
|
Definition
|
|
Term
What are the sympathetic receptor of male sex organ?
|
|
Definition
|
|
Term
What are the sympathetic receptor of pancreas?
|
|
Definition
|
|
Term
What are the sympathetic receptor of liver?
|
|
Definition
|
|
Term
What are the sympathetic receptor of uterus?
|
|
Definition
|
|
Term
| What is the action of a1 in eye? |
|
Definition
Contraction of radial
muscle of iris (mydriasis) |
|
|
Term
| What is the action of b R in eye? |
|
Definition
increased fluid inflow from & weak relaxation of ciliary
body |
|
|
Term
What is the action of b2 R in lung?
|
|
Definition
| Relaxation of bronchial muscles (increased airflow) |
|
|
Term
| What is the action of b1/2 R in heart? |
|
Definition
SA n.: increase in HR,
AV n.: increase in conduction
Ventricle: increase in contractility |
|
|
Term
| What is the action of a1 R in blood vessels? |
|
Definition
Constriction (skin, mucosa, glands, kidney)
[increase in BP] |
|
|
Term
What is the action of b2 R in blood vessels?
|
|
Definition
| Dilation (skeletal muscle) [decrease in BP] |
|
|
Term
What is the action of a1 & b2 R in stomach?
|
|
Definition
| Decrease in motility, tone & secretion |
|
|
Term
| What is the action of a1 & b2 R in intestine? |
|
Definition
| Decrease in motility & tone (constipation) |
|
|
Term
What is the action of a1 & b2 R in bladder?
|
|
Definition
| Relaxation (urinary hesitancy, retention) |
|
|
Term
| What is the sympathetic response of salivary, sweat, respiratory glands? |
|
Definition
|
|
Term
| What is the sympathetic response of adrenal medulla? |
|
Definition
| Epi release via nicotinic R |
|
|
Term
| What is the a1 R response in male sex organ? |
|
Definition
|
|
Term
What is the a2 R response in pancreas?
|
|
Definition
| Decreased secretion of insulin (glucose) |
|
|
Term
What is the a1 & B2 R response in liver?
|
|
Definition
| Gluconeogenesis, glycogenolysis |
|
|
Term
What is the B2 R response in uterus?
|
|
Definition
|
|
Term
| What is the muscarinic R response in eye? |
|
Definition
Constriction of sphincter muscles of iris (miosis)
Constriction of ciliary body (for near vision)
[[increase in outflow through trabecular meshwork ]] |
|
|
Term
What is the muscarinic R response in lung?
|
|
Definition
Constriction of bronchial muscles (decreased
airflow) |
|
|
Term
What is the muscarinic R response in heart?
|
|
Definition
| Decrease in heart rate and contractility |
|
|
Term
What is the muscarinic R response in blood vessels?
|
|
Definition
|
|
Term
| What is the muscarinic R response in stomach? |
|
Definition
| Increase in motility, tone, and secretion |
|
|
Term
What is the muscarinic R response in intestine?
|
|
Definition
| Increase in motility and tone (cramps, diarrhea) |
|
|
Term
What is the muscarinic R response in bladder?
|
|
Definition
| Contraction and relaxation (micturition) |
|
|
Term
| What is the muscarinic R response in sweat, salivary, respiratory glands? |
|
Definition
|
|
Term
What is the muscarinic R response in male sex organ?
|
|
Definition
|
|
Term
What is the muscarinic R response in uterus?
|
|
Definition
|
|
Term
| What is direct drug action? |
|
Definition
| direct action on receptor |
|
|
Term
What is indirect drug action?
|
|
Definition
| by increasing or decreasing synaptic NT levels |
|
|
Term
What is mixed drug action?
|
|
Definition
|
|
Term
| What are the 5 classification of autonomic drugs? |
|
Definition
Sympathomimetic or adrenergic drugs
Sympatholytic or adrenergic blocking drugs
Parasympathomimetic or cholinergic drugs Parasympatholytic or cholinergic blocking drugs Neuromuscular blocking drugs |
|
|
Term
| What are Sympathomimetic or adrenergic drugs like? |
|
Definition
|
|
Term
| What are Sympatholytic or adrenergic blocking drugs like? |
|
Definition
|
|
Term
| What are Parasympathomimetic or cholinergic drugs like? |
|
Definition
|
|
Term
| What are Parasympatholytic or cholinergic blocking drugs like? |
|
Definition
|
|
