Term
| Chlamydia Trachomatis Apperance |
|
Definition
Gram - like, but no peptidoglycan or LPS
Obligate intracellular pathogen, can't synth AA's |
|
|
Term
| Chlamydia Trachomatis Virulence |
|
Definition
IncA-G: involved in EB-RB transition, RB survival and replication
Endotoxin |
|
|
Term
| Chlamydia Trachomatis Reservoir |
|
Definition
|
|
Term
| Chlamydia Trachomatis Disease |
|
Definition
Tarp protein injected by Type III secretion, forms a recetpro for the bacteria
EBs enter by endocytosis, pinocytosis or phagocytosis (not trigger or zipper)
EBs turn into RBs and multiply, can fuse vacule with other vesicles for nutrients
IncA-G prevents lysosomal fusion
RBs change back into EBs before exiting
Symptoms caused by inflamm response
LGV (lymphogranuloma venerum): genital lesions, inflamm of draining lymph nodes, can spread systemically
Trachoma: chronic folluicular disease leading to blidness, eye discharge
Chlamydia: urethritis and discharge (men), vaginitis and discharge (women) and conjuctivitis and pneumonia (infants) |
|
|
Term
|
Definition
| Antibiotics: doxycycline (gets inside cell), azithromycin |
|
|
Term
| Neisseria Gonorrhoeae (GC) Apperance |
|
Definition
Gram - diplococci
Pyogenic
Oxidase +
Catalase +
Fastidious (needs chocolate agar, Thayer-Martin agar)
Ferments glucose only (distinguishes from neisseria meningitidis)
Facultative intracellular pathogen |
|
|
Term
| Neisseria Gonorrhoeae (GC) Virulence |
|
Definition
Type IV Pili: primary adhesions: extensive phase and antigenic variation
PI: porin, adhesion and invasion, resists phagolysosomal fusion and oxidative burst
PII: Opa, adhesion and invasion, extensive phase and antigenic variation
PIII: Rmp, block antibodies
Iron-binding proteins
Lipooligosaccharide (LOS): endotoxin, lacks the O-ag of LPS
IgA 1 Proteases
Peptidoglycan: cytotoxic |
|
|
Term
| Neisseria Gonorrhoeae (GC) Disease |
|
Definition
Infection process: direct contact leads to attachment
LOS and peptidogluycan damage surrounding epithelium, inflamm response
Multiply and spread across mucosal surface or thru to submucosa, into blood
Disease types: gonorrhea (STD): urethritis in men, vaginitis/cervicitis in women, pharyngitis, conjunctivitis, disseminated infection to rest of body, often joints, facilitates HIV transmission |
|
|
Term
| Nisseria Gonorrhoeae (GC) Toxin |
|
Definition
|
|
Term
| Nisseria Gonorrhoeae (GC) Transmission |
|
Definition
| Direct contact of mucosal surfaces (STD) |
|
|
Term
| Nisseria Gonorrhoeae (GC) Reservoir |
|
Definition
| Human mucosal epithelial surfaces |
|
|
Term
| Nisseria Gonorrhoeae (GC) Treat/Prev |
|
Definition
No vaccine
Most women have no symptoms, some men don't
Antibiotic resistant (beta-lactamase) |
|
|
