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Benign Prostatic Hyperplasia (BPH)
Benign Prostatic Hyperplasia (BPH)
24
Pharmacology
Professional
09/26/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
How many phases of growth does the prostate have?
Definition

Two. First phase at puberty and the second at 25 (continues to grow from that age on)

Term
What are some drugs that will worsen BPH symptoms
Definition

Combination cold medicines, decongestants, antihistamines and medications with anticholinergic side effects will worsen symptoms. Diuretics, if they must be used, should be dosed early in the day.

Term
What is treatment based on?
Definition

primarily on the patient's perception of how bothered they are by the symptoms

Term
What class of medicine is initally started in BPH?
Definition

5-alpha clockers are used, alone or in combination with the 5-alpha reductase inhibitors.

Term
What natural product is used to treat BPH?
Definition
Saw Palmetto
Term
How do alpha blockers work?
Definition

relax the smooth muscle of the prostate and bladder neck to improve urine flow

 

Term

There are 3 types of alpha receptors: 1A (prostate primarily has these receptors), 1B and 1D. Nonselective alpha blockers results in more orthostasis/dizzinesss/fatigue/HA than the selective agents. Whata are the non-selective alpha blockers?

 

 

Definition

Terazosin

Doxazosin

Term
Brand name of Terazosin
Definition
Hytrin
Term
Brand name of Doxazosin?
Definition
Cardura
Term
Do alpha blockers shrink the prostate?
Definition
NO! and the do not change PSA levels!
Term
Side effects of non-selective alpha blockers?
Definition
orthostatic hypotension, dizziness, fatigue
Term
[image]
Definition
Statement. Not a question.
Term
Name the selective alpha blockers
Definition

Tamsulosin

Alfuzosin

 

 

Term
Brand name for Tamsulosin
Definition
Flomax
Term
normal dose for tamsulosin
Definition
0.4mg
Term
[image]
Definition
Statement. Not a question.
Term
Name an obvious percaution for alpha blockers (think men)
Definition
Alpha blockers and PDE5 inhibitors!
Term
How do 5-alpha reductase inhibitors work?
Definition

Inhibit the 5-alpha reductase enzyme. Which blocks the conversion of testosterone to DHT

Term
Name the 5-alpha reductase inhibitors
Definition

Finasteride

Dutasteride

Term
Brand name for Finasteride
Definition
Proscar
Term
Brand name for Dutasteride
Definition
Avodart
Term
What pregnancy category are 5-alpha reductase inhibitors?
Definition

Preg Cat X

 

Pregnant women (should not handle nor take these meds: can be absorbed through skin; can be detrimental to fetus); semes of male taking this drugs may present a danger

Term
Do 5-alpha reductase inhibtors shrink the prostate?
Definition

YES! F-alpha reductase inhibitors SHRINK the prostate and decrease PSA levels

Term
[image]
Definition
Statement. Not a question.
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