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Microtubule Associated Proteins- stabilizes plus ends microtubules |
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Microtuble Associated Proteins- holds microtubules at a longer distance |
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Microtubule Associated Protein-
holds microtubules at a shorter distance |
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Microtubule Associated Proteins- Binds microtubule subunits so that it prevents assembly |
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Severs filaments and binds to the plus end |
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Can bind to actin filaments making a meshwork |
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Recruits actin subunits and speeds elongation |
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Binds actin subunits and prevents elongation |
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Nucleates assembly (easier to start with) and actin subunits add on |
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Recruit actin to membranes by binding receptors |
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Moves chromosomes to the plus end (away from centrosome) |
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Two pairs of legs (no head) plus end directed (away from centrosome) resulting in MTs pulling apart |
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Minus end directed (towards centrosome) bringing MTs together closer |
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Minus end directed (towards centrosome) head on PM and legs on MT. Pulls centrosomes apart |
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G-Protein Calcium Pathway
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Vasopressin binds receptor and induces a conformational change Gα becomes activated by binding GTP Gα dissociates from βγ subunits Gα actiates phospholipase C PLC cleaves PI 4,5 bisphosphate (PIP2) into IP3 and DAG IP3 diffuses and opens ER localized Ca2+| channels |
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Acts as a precursor to MT formation |
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proteins in the ER have this sequence.
If accidentally goes to golgi (low pH, acidic), has receptors with high affinity. Low affinity at ER, proteins come off |
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recruits COPII at ER (GTPases) |
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recruits Clathrin and COP1 at golgi (ATPase) |
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co-translationally translocated |
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Definition
made in a lill protein (eg. Na+ K+ pump do this) |
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Ribonuclearprotein that holds translation in rough ER, faces the cytosol |
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Normal epithelium-> polyp->dislasia->carcinoma in situ->malignant carcinoma(metastisis) |
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G-Protein Pathway: Production of cAMP |
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G-Protein: Ca Channel Regulation |
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Calmodulin as a Memory Protein |
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