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Biochem 1st quiz
Signal transduction, etc.
33
Biochemistry
Graduate
09/02/2010

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Term
Signaling molecules
Definition
Antigens, hormones, neurotransmitters, touch
Term
Name four features of signaling transducing systems
Definition
Specificity, amplification, desensitization, integration
Term
Name the 5 different receptor types
Definition
G-protein, Enzymes, Ligand-gated channels, Integrin Receptors, Nuclear receptors
Term
Four typical ligands
Definition
Prganic molecules(adrenaline), Polysaccharides(heparin), Peptides(insulin), Proteins(VEGF)
Term
Name the 6 different types of Signal Transducers
Definition
G-proteins(epinephrine), Tyrosine Kinase Receptor(proteins), Guanylyl Cyclase(cGMP), Integrin(adhesion receptor), Gated ion channel(ACh), Nuclear Receptor(steroids)
Term
Close to 50% of all drugs on the market target what type of receptor?
Definition
G-Protein coupled receptors
Term
Which type of receptor mediates the effects of epinephrine?
Definition
beta-adrenergic receptors
Term
How do beta-adrenergic recpetors cause effects?
Definition
via cAMP
Term
Agonist
Definition
a structurally similar molecule to the binding ligand
Term
Isoproterenol
Definition
agonist drug for epinephrine used for patients with bradycardias and heart block
Term
Propranolol
Definition
antagonist drug for epinephrine used to lower BP and HR (beta-blocker)
Term
Name the 3 essential components of a G-protein
Definition
7 transmembrane helical segments, effector EZ generating a 2nd messenger, Gprotein that acitvates a cascade
Term
Name some signals that use cAMP as a 2nd messenger
Definition
Corticotropin(cortisol), Glucagon(insulin release), Serotonin(depression-SSRI), Somatostatin(inhibits insulin)
Term
Name some signals that use Phospholipase C,IP3, and Ca2+
Definition
Angiotension II(vasoconstrictor-ace inhibitors), Vasopressin(water retention)
Term
Name the most common catalytic domain receptor type
Definition
Tyrosine kinase
Term
Explain how TKR works
Definition
It auto-phosphorylates itself and causes a conformational change allowing binding for specific proteins/adds phosphate group to tyrosine in specific proteins
Term
What type of receptor is EGFR?
Definition
TKR
Term
Cancer can result when what receptor has a mutation?
Definition
EGFR
Term
All EGF pathways lead to what two main results in the cell?
Definition
Protein synthesis and cell survival/proliferation
Term
Name two places that a cancer drug could be used to block EGFR
Definition
Ligand binding receptor and TK inhibitors)specifically prevents Phosp.)
Term
Name a monoclonal antibody that can be used in the treatment of cancer concerning the EGFR
Definition
Cetuximab-binds to EC domain preventing ligand binding
Term
Name a TKI that is used in the treatment of cancer concerning the EGFR
Definition
Gefitinib-blocks (P) of TK by binding to the ATP binding site
Term
Name the type of receptor that acts in the nucleus and alters gene expression
Definition
Nuclear receptors
Term
Name the drug that is used in the treatment cancer where cell division is effected by estrogen production
Definition
Tamoxifen-antagonist for estrogen
Term
Name the phases of the cell cycle in the order they occurr
Definition
G1, S, G2, Mitosis, G0
Term
What process occurs during G1?
Definition
Protein and RNA synthesis
Term
What occurs during the S phase?
Definition
DNA synthesis
Term
What events occurs during the G2 phase?
Definition
Preparation for cell division
Term
What occurs during Mitosis?
Definition
division and cytokinesis of the cell
Term
What occurs during the G0 phase?
Definition
Cells are checked for mutations and either destroyed or released to their destinations
Term
What controls the timing of the cell cycle?
Definition
Cyclin Dependent protein kinase
Term
Name the regulatory subunit, catalytic subunit, and route of activity for the CDPK
Definition
Reg. subunit: cyclin
cat. subunit: PK
activity:(P)
Term
What phase does CDK work in?
Definition
G0 phase
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