Term
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Definition
It inhibits Complex 1
- NADH can't give electrons to Complex 1 (NADH pools)
- CoQ can't pick up electrons from Complex 1
- CoQ CAN pick up electrons from TCA cycle
- Complex 1 usually gets 4 H+ across but now you can't, so you lose 1 ATP
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Term
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Definition
It inhibits Complex II (CoQ)
Complex 1 can still get electrons to CoQ so you still get H+
It is a problem with TCA cycle
Everything acts the way it is supposed to except Complex II |
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Term
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Definition
It inhibits Comlpex III
CoQ can't give electrons to Complex III
CoQ stays reduced
After some time, all of your CoQ is reduced.
Then, when Q wants to get rid of electrons, it can't.
This blocks Complex II
Complex I can't get rid of electrons either so it blocks up
It blocks both pathways of electrons. THis is bad for cell |
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Term
| What do CO2, N3, and CCN do |
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Definition
They block Complex IV
This blocks the passage of electrons from Complex I and II
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