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is the investigation of gene structure and genetic info processing |
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Study of chemical substances and vital processes occurring in living organisms |
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Study of the effect of genetic differences of orgs |
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Is the set of mechanisms whereby cells control the timing of gene product synthesis in response to environmental cues |
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Complete DNA base seq in an org |
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complete set of RNA molecules that are transcribed from a cells genome |
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entire set of proteins synthesized by the cell |
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Sum of all the low molecular weight metabolite molecules produced by a cell as the result of its gene expression. |
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Nitrogen bases on dna face |
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Negative charged sugar phosphate face |
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What are the 5 stabilizing forces of the double helix |
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-Hydrophobic interactions
-Hydrogen bonds
-BAse stacking
-Hydration
-Electrostatic interactions |
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involve one base pair mutation |
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type of point mutation where purine will connect to purine |
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type of point mutation where purine + pyrimidine |
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Define Depurination Reaction |
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spontaneous hydrolysis causes 1000 purines lost a day, usually caught by DNA repair mechanisms |
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In demamination reactions what happens? |
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C chnges to U so base pair replication is distributed and cannot occur |
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What happens during Ionizing Radiation ( uv rays, x-rays, gamma rays) |
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-Strand breaks
-Ring openings
-Base modifications
-dna protein cross linking- dna becomes bound to certain proteins and can't let go if it needs to |
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Describe pyrimidine dimers and name the most popular |
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-most common are thymidine dimers
-found in Ionization radiation such as in Tanning beds
-thymines become bound to each other and DNA is bulky and unable to move |
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-foregin subs that can damage DNA. Either naturally occurring or manmade |
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-Base analogues-similar to bases but not th same and they then get stuck in the strand
-Alkylating Agents-
-Nonalkylating Agents-
-Intercalating Agents-Acridine stuck between bases of DNa |
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Basic rules of inheritance |
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Found chemical composition of DNA |
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:Transformation Principle" trying to develop a strep Pneumonia vaccine.
Live R cells are mixed with killed S cells which are then injected into killed S cells >mice die |
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-dehydrated DNS
-Lose water
-right handed
-wider diameter |
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-salt form
-highly humid conformations
-right handed
-90 degree angle |
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-Zig zag
-left handed
-more base paris per turn |
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Certain segments of DNa form higher ordered structures called________ |
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-inverted repeats forming cruciforms, palindromic regions within genome |
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