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Biochem Test 2 Carbs/Lipids
N/A
47
Biochemistry
Undergraduate 3
11/10/2014

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Term
Aldose carbs have an
Definition
aldehyde1
Term
4 types of aldose carbs
Definition
aldotriose
aldotetroses
aldopentoses
aldohexoses
Term
D or L is determined by
Definition
chiral carbon furthest from the aldehyde/ketone
Term
If –OH is on the right in Fisher projection, then is
Definition
D-sugar
Term
If -OH is on the left, then
Definition
L-sugar
Term
Ketose sugars have a
Definition
ketone group
Term
alcohol + aldehyde =
Definition
hemiacetal
Term
alcohol + ketone =
Definition
hemiketal
Term
Hemiacetal
Definition
These structures
are stable in carbohydrates
and are the results of linear
to cyclic interconversion
of sugars
Term
Hemiketal
Definition
In enzyme inhibitors
aldehyde-alcohol products
often will collapse
back into the reactants
at slow rate
Sometimes a called
“slow, tight binding”
inhibitors
Term
alpha
Definition
opposite sides of ring
Term
beta
Definition
same side of ring
Term
Glycosidic bonds connect
Definition
sugar to another group
at anomeric carbon
Term
Galactose + glucose
Definition
lactose
Term
Glucose + fructose
Definition
sucrose
Term
Sugar and water
Definition
hydrophyllic
Term
Cellulose
Definition
structural polysaccharide found in plants
Term
Glucose + Glucose
Definition
cellulose
Term
Chitin
Definition
is a structural polysaccharide found in insects, fungi, and crusteceans
Term
N-acetyglucosamine (x2)
Definition
chitin
Term
Amylose
Definition
is a storage polysaccharide
Term
Glycosaminoglycans are
Definition
multi-functional molecules
Term
Heparin
Definition
-glycosaminoglycan
-involved in blood clotting
Term
Heparin enhances the activity of
Definition
Anti-thrombin III
Term
OSC can inhibit
Definition
blood clotting
Term
APTT =
Definition
activated partial thromboplastin time
Term
APTT
Definition
Clotting time
Values of approximately 25 to 35 are considered “normal”
Term
Factor XIIa regulates
Definition
the contact activation pathway
Term
Factor XIIa is activated by
Definition
negatively charged surfaces and high-molecular-weight kininogen
Leads to activation of Factors VII, XI, and prekallikrein
Term
Bradykinin stimulates:
Definition
blood vessel dilation
immune system
Term
Anaphylatoxins
Definition
which can produce a local inflammation response
Term
Inflammation pathway
Definition
Over Sulfated Chondroitin Sulfate ->
Activation of Kallikrein ->
Release of C5a
and C3a
Term
Blood vessel dilation
Definition
Over Sulfated Chondroitin Sulfate ->
Activation of Kallikrein ->
Bradykinin release
Term
Glycosylation patterns are recognized by various
Definition
cell surface proteins
Term
Lectins bind to
Definition
carbs
Term
Lipids are for
Definition
cellular fat storage
Term
Fatty acids are
Definition
structurally diverse
Term
Fatty acid structure
Definition
Carbon hydrogen chain with a COO-/COOH at one end
Term
Backbone of a lipid- glycerol
Definition
3 carbon backbone

Can connect to up to 3 fatty acids

Sometimes have other groups (See a later slide)
Term
3 properties of Steroids and Cholesterol
Definition
Amphipathic or hydrophobic
4 fused rings
Structural and signaling molecules
Term
Rickets
Definition
caused by vitamin D deficiency including lack of sunlight. Symptoms include bone weakness and deformities.
Term
Eicosanoids
Definition
involved in pain and fever in humans
Term
______ Diffusion is common in bilayers
Definition
lateral
Term
Cell membranes contain
Definition
carbohydrates, lipids and proteins
Term
Proteins can be modified to associate with
Definition
cell membranes
Term
Hydropathy plots can predict
Definition
whether a protein has a transmembrane segment
Term
For TM region need to meet 2 requirements
Definition
High +ΔG

Long enough segment to span cell membrane (~15 to 20 AAs)
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