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Biochemistry
TCA cycle
13
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Graduate
02/03/2009

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Term
pyruvate dehydrogenase
Definition
what enzyme converts pyruvate to acetyl Coa
Term
PDH phosphatase
Definition
this enzyme activates E1
Term
cAMP independent PDH kinase
Definition
this enzyme inhibits E1
Term
E2
Definition
this enzyme requires lipoic acid and CoA
Term
E3
Definition
this enzyme requires FAD and NAD+
Term
congenital lactic acidosis
Definition
A deficiency in the E1 component of the pyruvate dehydrogenase complex is the most common biochemical cause of? this causes pyruvate to be shunted to lactic acid via lactate dehydrogenase
Term
arsenic poisoning
Definition
pyruvate dehydrogenase, α-ketoglutarate dehydrogenase (see below), and branched-chain α-keto acid dehydrogenase are all inhibited by?
Term
citrate synthase
Definition
The condensation of acetyl CoA and oxaloacetate to form citrate (a tricarboxylic acid) is catalyzed by
Term
PFK; acetyl coa carboxylase
Definition
Citrate also inhibits? and activates ?
Term
fluoroacetate
Definition
Aconitase is inhibited by
Term
substrate-level phosphorylation
Definition
The generation of GTP by succinate thiokinase is another example of
Term
succinate dehydrogenase
Definition
is the only enzyme of the TCA cycle that is embedded in the inner mitochondrial membrane
Term
asparatic acid
Definition
Oxaloacetate is also produced by the transamination of the amino acid
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