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Biology 111 Test #1
Chapters 1-4
110
Biology
Undergraduate 1
01/31/2012

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Term
2 Major Ways of Exploring Biology
Definition
1. Discovery Biology
2. Experimental Biology (Scientific Method)
Term
2 Theories Define Biological Science
Definition
-Cell Theory
-Theory of Evolution
Term
Cell Theory
Definition
-All living things are composed of cells
-All cells come from pre-existing cells
-Cells are the basic units of life
Term
WHO Discovered Cells?
Definition
Robert Hooke- cellulae- dead cells

Leewenhoek-animalcules- sperm, pond water
Term
Where Do Cells Come From?
Definition
Pre-existing cells
-process called spontaneous generation
Term
Theory of Evolution
Definition
-Descent from a common ancestor (pattern)
-Darwin observed these patterns
-Modifications due to natural selection (survival of the fittest)
Term
Adaptations
Definition
heritable traits that increase fitness (the attribute to survive conditions & reproduce)
Term
Artificial Selection
Definition
Man chooses certain traits-used a lot in agriculture
Term
Tree of Life
Definition
BACTERIA

LUCA ARCHAEA

EUKARYA


Last Universal Common Ancestor
Term
Taxonomy
Definition
(Linnaeus)
Domain
Kingdom
Phyllum
Class
Order
Family
Genus
Species

Dumb King Phillip Can Order Free Grape Soda
Term
Domain Bacteria & Domain Archaea
Definition
Prokaryotes (Prekernal)
-No nucleus
-No membraneous Organelles
-Single Celled Organisms
Term
Domain Eukarya
Definition
Eukaryotes (True Kernal)
-Have a nucleus
-Single or multi-celled

(Protists, Fungi, Plants, Animals)
Term
Life Defined
Definition
-cells
-energy (can capture and use)
-information (DNA, RNA)
-replication (species can survive)
-evolution (populations adapt)
Term
Reductionist Approach
Definition
Breaking down components, build back up
Term
Levels of Organization
Definition
Atom
Molecule
Cell
Tissue
Organ
Organ System
Multi-celled organism
Population
Community
Ecosystem
Biosphere
Term
Theory of Chemical Evolution
Definition
Abiotic Synthesis
-One time spontaneous generation event
Term
Building Blocks: Elements
Definition
-Fundamental basis of matter
-Cannot be broken down
-92 naturally occur
-Each is composed by 1 atom type
Term
Most Common Elements in Living Organisms
Definition
Hydrogen
Carbon
Nitrogen
Oxygen

Make up 96% of all living things
Term
Trace Elements
Definition
Make up less that .01% of living things
Term
Iodine Deficiency
Definition
Result in goiters
Term
What Determines Element Behavior?
Definition
Atomic Structure
Term
Atom
Definition
-Smallest particle that retain properties of an element
-Consists of subatomic particles
Protons
Electrons
Neutrons
Term
Protons
Definition
-Found in nucleus
-1 amu
-defines the atom
- (+) POSITIVE CHARGE
Term
Electrons
Definition
-Found outside of nucleus
-No measurable weight
-Determines behavior
- (-) NEGATIVE CHARGE
Term
Neutrons
Definition
-Found in nucleus
-1 amu
-Defines isotope
-NO CHARGE
Term
To Be Electrically Neutral
Definition
# of protons ALWAYS = # of electrons
Term
Atomic Notation
Definition
-Symbol
-atomic number (# of protons) on bottom, NEVER CHANGES
-mass number (# of protons + neutrons) CAN CHANGE
Term
Isotopes
Definition
-atoms w/ variable # of neutrons -can make nucleus unstable because they emit energy particles
Term
Electrons & Atom Behavior
Definition
-Determines if atoms will interact or bond
-Based off of numbers and arrangements
Term
Orbitals
Definition
-Hold electrons
-electron shells

1st layer- max of 2 electrons
2nd, 3rd, 4th etc.- max of 8 electrons
Term
Outermost Electron Shell
Definition
-Valence Shell
-Full= Stability (Inert & Un reactive)
-Vacancies= Reactive (Not full)
-Valence - number of unpaired electrons
Term
Chemical Bonds
Definition
-Fill electron vacancies
-Covalent bonds (shared)
-Ionic bonds (transfer)
Term
Covalent Bonds
Definition
MOST STABLE
-atoms share a pair(s) of electrons to fill outermost shell
-bonds can be single, double, or triple
Term
Non-polar
Definition
Equal sharing of electrons
Term
Polar
Definition
Unequal sharing of electrons
- Due to electronegativity
Term
Electronegativity
Definition
one atom has greater pull on electron
-leads to partial charge
Term
Representing Molecules
Definition
-Molecular format
-Structural formulas
-Ball & Stick models
-Space filling models
Term
Ionic Bonds
Definition
-atoms transfer electrons
-changes proton; electron ratios
Term
Ions
Definition
Charged atoms or molecules
-cation (+)
-anion (-)
Unalike charges attract forming bond
Term
Compound
Definition
2 or more atoms bonded in a given ratio
Term
Molecular Weight
Definition
Sum of mass numbers of all atoms
Term
Chemical Equilibrium
Definition
Stable yet continual shift from forward to reverse
Term
Metabolism
Definition
The sum of chemical reactions
-how cells do work
-requires energy and and aqueous solution
Term
Energy
Definition
Capacity to do work
Term
Potential Energy
Definition
Stored
-Chemical -stored in bonds
Term
Kinetic Energy
Definition
In motion
-Thermal -molecular motion
Measured in temp
-Heat -uncontained energy
Transferred thermal energy
Term
Thermodynamics
Definition
The study of energy
Term
2 Laws of Thermodynamics
Definition
1. Energy cannot be created or destroyed, only transformed or transferred

2. Natural tendency toward disorder or ENTROPY
Term
Organisms Can Increase Order By...
Definition
Maximizing energy use
Term
Energy Coupling
Definition
cells combine chemical reactions
-energy releasing reactions with energy requiring reactions
Term
Exergonic Reactions
Definition
Release energy
-spontaneous
Term
Endergonic Reactions
Definition
Require energy input
-non spontaneous
Term
Water
Definition
-essential to life
-66% of body weight
-exist in 3 physical states: solid, liquid, and gas
Term
Properties of Water
Definition
-Polarity
-Hydrogen bonding
-Solvent
-Cohesion
-Temperature stabilizing capabilities
Term
Water is a Polar Covalent Molecule, Meaning..
Definition
-no net charge
-leads to hydrogen bonding
Term
Hydrogen Bonds
Definition
-weak bonds between polar molecules or polar molecules and ions.
-break and reform easily
-strong in high numbers
Term
Water as a Solvent
Definition
-dissociates many solutes into solution
Hydrophilic or Hydrophobic
Term
Hydrophilic
Definition
easily dissolved
-ions and polar molecules
Term
Hydrophobic
Definition
do not dissolve
-non polar, water repels (i.e. oil)
Term
Cohesive and Adhesive Properties
Definition
-water sticks to itself and other polar/ charged stuff
-life is dependent on these properties
-cohesion creates surface tension
:water's property to resist breaking under pressure
Term
Temperature Stabilizing Effects
Definition
-high capacity to absorb heat energy
Term
High Specific Heat
Definition
amount of energy necessary to raise one gram of water one degrees Celsius
-takes much energy to increase temperature
Term
High Heat of Vaporization
Definition
-much energy to convert from liquid to a gas
Term
Temperature Stabilization: ICE
Definition
less dense than liquid water
causes it to float
Term
Alkaline
Definition
less H+'s, more OH+'s
Term
Acid
Definition
more H+'s, less OH+'s
Term
pH
Definition
Hydrogen power
0-14
Neutral at 7

[H+] using logarithmic- goes up or down by 10 times
Term
Buffers
Definition
compounds that minimize pH shifts
Term
Organic Compounds
Definition
C-H
or
C-C
Term
Carbon's Importance
Definition
bonding capacity
-covalent bonds
-can bond w/ up to 4 atoms

leads to diverse molecular shapes
Term
Isomers
Definition
same molecular formula, but different structural formula
Term
Optical Isomers
Definition
mirror images
(L-Dopa & D-Dopa)
Term
Functional Groups
Definition
-covalently bonded atoms or clusters of atoms
-gives carbon skeleton properties
-participates in chemical reactions
-gives molecular diversity
Term
Stages of Chemical Evolution
Definition
1. Synthesis of organic molecules
2. Formation of "building blocks" :prebiotic soup
3. Polymerization of large molecules
4. Large molecules could replicate
Term
Polymers
Definition
-Large chain molecules consisting of smaller similar subunits (monomers)
-Linking process is polymerization
-Assembled and disassembled by 2 chemical reactions
Term
Dehydration Synthesis
Definition
1. Condensation reaction: monomer in, water out
2. Hydrolysis: water in, monomer out
Term
Types of Proteins
Definition
involved in cell structure and function
-structural; support
-storage; storage of amino acids
-transport; of other substances
-hormonal; coordination of an organism's activities
-receptor; response of cell to chemical stimuli
-contractile; movement
-defensive; protection against disease
-enzymatic; selective acceleration of chemical reactions
Term
What are Proteins?
Definition
-folded polymers of amino acids
-diversity based on the arrangement of 20 amino acids
Term
Amino Acids
Definition
Contain:
-Amine group
-Carboxyl group
-R group
Term
R Group
Definition
-distinguishes each amino acid
-gives each amino acid specific properties
-determine reactivity and folding of polymer
Term
Protein Synthesis: Polymerization
Definition
-Linking amino acid monomers together forming chains
-Peptide bonds form between the monomers

-Oligopeptides- 50 or less
-Polypeptides- 50 or more

-Upon interaction and folding ia a protein
Term
Protein Structure
Definition
-most diverse class of molecules for shape
-form fits function
-4 levels of organization (primary,secondary, tertiary, quaternary)
Term
Primary Structure
Definition
-Unique sequence of amino acids
-controls final shapes
-instructed by DNA
-single amino acid change disrupts the final shape and function
Term
Secondary Structure
Definition
involves hydrogen bonding between atoms of the polypeptide's backbone
2 basic structures
-helix
-pleated sheets
Term
Tertiary Structure
Definition
Binding between R groups form irregular contortions
Term
Globular Proteins
Definition
function as enzymes
Term
Fibrous Proteins
Definition
collagen, tendons, ligaments
Term
Quaternary Structure
Definition
a combination of two or more polypeptides interacting to form a single structure
Term
Folding and Function
Definition
Dependent on the cellular enviornment
-pH, temp, and salts
Molecular chaperones can facilitate folding
Term
Prions
Definition
-infectious proteins (virus-like)
-proteins that are misfolded
Term
Enzymes
Definition
-catalytic proteins- accelerate chemical reactions
-end in -ase
-one enzyme for one substrate (reactants)
-not consumed or altered by reaction
-maximize energy use
Term
Chemical Reactions: Barriers
Definition
Energy barriers
-prevent spontaneous breakdown of reactants

Overcome barriers
-kinetic energy increases
-reactants collide and bonds break/reform: transition state
Term
Enzyme Action
Definition
-decrease energy input necessary to reach the transition state
-lowers activation energy (energy required to initiate chemical reaction
Term
Enzymes are Substrate Specific
Definition
-each type of cellular reaction is catalyzed by a specific enzyme
Term
Active Site
Definition
pocket for substrate binding
-induced fit occurs upon binding
-shape change of enzyme
Term
Catalytic Cycle of an Enzyme
Definition
1. Initiation: Reactants bind for enzyme-substrate complex
2. Transition State Facilitation: enzyme induced fit lowers Ea
3. Termination: Products released, enzyme is unaltered
Term
Enzyme Helpers
Definition
-inorganic metal ions
-organic molecules-coenzymes
Term
Enzyme Activity
Definition
-affected by pH, temp, and salts
-excess substrate
Term
Enzyme Regulation
Definition
Competitive inhibition-something in the way
Allosteric inhibition-shape changes
-activation
-deactivation
Term
Types of Nucleic Acids
Definition
DNA
RNA
Term
Nucleotides' 3 Components
Definition
-5 Carbon Sugar
-Phosphate Group
-Nitrogen Base
Term
N-Bases 2 Categories
Definition
Pyrimidines
Purines
Term
DNA
Definition
A-T,G-C
Double Helix-strands run anti parallel
Term
RNA
Definition
A-U,G-C
Term
Nucleotides Polymerize
Definition
Occurs in 5 prime to 3 prime direction
Joined by phosphodiester bonds
Term
Endergonic
Definition
energy form phosphorylated molecules
Term
Polynucleotide Strand
Definition
Sugar phosphate backbone
Term
DNA Synthesis
Definition
1. Strands separate-hydrogen bonds break
2. Complementary base pairing to template
3. Polymerization- sugar phosphate backbone is sealed
Term
RNA Primary Structure
Definition
Single polynucleotide strand
carries out DNA instructions by complementary strands
Term
RNA Secondary Structure
Definition
-H-Bonding within a single strand
-3 types: mRNA, tRNA, rRNA
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