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Biomed test 2
Biomed
91
Other
Graduate
06/19/2012

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Term
cortisol exerts _____ feedback
Definition
negative
Term
Cortisol effects____
Definition
the hypothalamus and anterior pituitary to suppress its own secreations
Term
exogenous glucocorticoid drug would result in...
Definition
adrenal supression
Term
cortisol is the opposite of___
Definition
insulin
Term
uses for glucocorticoids
Definition
replacement therapy- adrenal insufficiency
most frequent- antininflammatory effects
allergic reactions
prevention of graft rejection
Term
adverse drug reactions
Definition
osteoporosis, peptic ulceration, cataracts, adrenal supression
Term
effects of NSAID drugs ( adverse)
Definition
GI tract- irritation, gastritis, peptic ulcer disease and bleeding
Term
NSAID drug example
Definition
aspirin
Term
side effects of opioid anagesics
Definition
miosis, sedation,supression of cough, tolerance to pain
Term
signs of opioid toxicity
Definition
coma, pinpoint pupils, respiratory depression
Term
methadone
Definition
detoxification and temporary maintence treatement of opioid addiction
Term
codeine
Definition
antitussive, antidiarrheal
low potency agonists for mild to moderate pain
Term
opiod antagonists
Definition
very rapidly reverses opioid induced respiratory depression
precipitate withdrawel syndrome in physical dependence-- naloxone
Term
3 categories of trauma
Definition
early
intermediate
late
Term
Early stage soft tissue
Definition
bleeding/ swelling
disruption of musculoskelteal units
vascular disruption
Term
direct vs indirec injury
Definition
direct- bone
indirect- blow or traction
Term
open fracture
Definition
bone sticks out through skin
Term
early stage: systemic
Definition
bleeding or hemorrahigc shock
Term
early stage: neruo
Definition
nerves are injured from traction
Term
early stage: bone or joint
Definition
open fracture
Term
intermediate soft tissue
Definition
compartment syndrome, decreased sensation, paleness,severe pain, weakness
Term
intermediate systemic
Definition
thromboembolism
pulmonary/fat emobolism 24-72 hours post injury
Term
intermediate joint/bone
Definition
gaseous gangrene
tetanus
Term
signs of gangrene
Definition
local pain, swelling, thing brown drainage, musty odor, brownze discoloration of skin; fever, tachycardaia, somnolence, shock, eventually coma
Term
tetanus
Definition
7-14 days post trauma
muscle pain, stiffness, progressive rigidity convulsion and death
Term
late stage: soft tissue
Definition
contracture, complex regional pain syndrome
Term
late stage: bone and joint
Definition
malunion, nonunion
chronic osteomyelitis, necrosis
Term
nonunion is the result of____
Definition
infection, inadequate immobilization, distraction to fx site, disruption of blood flow, ill-conceived surgical intervention
Term
chronic osteomyelitis
Definition
result of bacterial infection of bone
occurs in open fracture or surgical intervention of closed fracture, bacteria can live in dead bone which can lead to amputation, becuase there is no way to get the antibiotic to the dead bone without blood flow
Term
aseptic necrosis
Definition
common in fxs and dislocations where bone is rendered ischemic
restoration of blood flow must be rapid
associated with decreased ROM and 2 to degenerative arthritis
Term
degenerative arthritis
Definition
usually a complication of intra articular fractures
Term
transverse fracture
Definition
width wise straight across, result of simple angulatory forces
Term
spiral fracture
Definition
result of torsion
Term
oblique fracture
Definition
angulated break; occurs on an angle
Term
comminuted fracture
Definition
bone is broken in three or more fragments, crush injury--> often amputated
Term
3 parts of bone
Definition
metaphyseal- soft bone ends
diaphyseal- thick shaft
epiphyseal- grow plate in long bones
Term
TTWB
Definition
less than 15lbs of weight; balence purpses only
Term
PWB
Definition
about 30lbs
Term
acetabular fracture
Definition
3 months of immobility prior to WB status
Term
femur neck fracture
Definition
leg appears shortened, external rotation healing process 12-16 wks
Term
tibial plateau
Definition
car bumper injury
tx- hinge brace most common cause is axial loading
Term
tibial shaft
Definition
high energy injuryings- falling, jumping tend to be spiral fractures
Term
what is the most common joint disorder?
Definition
osteoarthritis; degenerative joint disease ( wear and tear)
Term
joints affected by OA
Definition
knee, hip, spine, fingers, thumb, big toe, neck
Term
osteophyte
Definition
spur formed when osteoblast formation increases while reorption decreases
Term
nodal arthritis
Definition
bony enlargements of distal and proximal IP joints

Heberden- distally
Bouchard- proximal
Term
OA is greater in what popualation?
Definition
women (hands), 25% of the population ( 67 million) older than 45

men are dx before 45 and women are dx after 45
Term
crepitus
Definition
grating of joints with movement
Term
in developmental trauma disorder what are the percentages of perpertrators?
Definition
77% parents
11% relatives
2% other child care provider
10% unknown
Term
what percentage of perpertrators are under the age of 40?
Definition
81%
Term
what percent of perps. are women
Definition
61%- neglect and maltreatment
Term
what age group is at the hightest risk of DTD
Definition
67% are under 1, 80% under 3
Term
types of attachement
Definition
avoidance- rejection and failure to provide basic emotional/physical support

ambivalent- detachment and neglect

disorganization- traumatized, repeated exposure to uncontrolled and unpredictable stress
Term
structures develop into eyes at___
Definition
4 weeks gestation
Term
eyes have already formed at ____
Definition
7 weeks gestation
Term
vision pathways to cortext is developed but the visual structures are still immature at ____
Definition
23-24 weeks gestation
Term
anopthalmia
Definition
lack of eyes
Term
hemihypertrophy
Definition
eyes migrate closer together leaadig to widely spaced eyes
Term
intrauterine infections can cause____
Definition
cataracts, glaucoma, or chorioretinitis
Term
chorioretinitis
Definition
inflammation of the choroid and retinal layers of the eye
Term
leading causes of blindness in children are _____
Definition
cortical vision impairments
reinopathy of prematurity
optic nerve hypoplasia
Term
CHARGE
Definition
coloboma of eye
heart defect
choanal Atresia
retarded growth/development
genital abnormalities
ear malformation
Term
4 C's
Definition
coloboma
choanal atresia
cranial nerve defect
charge ears
Term
coloboma
Definition
missing tissue- congenital defect of the eye caused by failure of complete growth in affected area
Term
nystagmus
Definition
unsteady jiggling of the eye
Term
cortical vision impairment
Definition
bran based visual impairment; temp or perm.
Term
color blindness
Definition
x linked trait in 8% of men
red/green is the most common
Term
retinopathy of prematurity
Definition
most common cause of retinal damage in premies
25% of infants less than 2500grams
vascular damage to retina
Term
myopia
Definition
nearsighteness
Term
stage 1 or 2 of ROP
Definition
may not require surgery
Term
stage 3 of ROP
Definition
laswer or cryotherapy
Term
stage 4 of ROP
Definition
partial retinal detachment, surgeical procedure- scleral uckle or vitrectomy
Term
stage 5 of ROP
Definition
end stage, complete retinal detahcment, surgery ( open-sky)
Term
other retinal disorders
Definition
shaken infant syndrome- retinal hmorrahges
toxoplasmosis
tay-sachs- abnormal cellular material in retina
retinal tumors- retinoblastoma
Term
optic nerve hypoplasia
Definition
small thin optic nerve transmits impair information to brain , sensory systagmus is observed
Term
Glacoma
Definition
increase intraocular pressure, hardening of eye, damage to cornea
Term
congenital glacoma
Definition
occurs 1st year, blockage of liquid flow from abnormal membran that covers the meshwork
Term
acquired glaucoma
Definition
secondary to infection,ROP, occular inflammation, eye truama
Term
hyperopia
Definition
far sightness- most common in children
Term
astigmatism
Definition
surface of cornea has ellipical rather than sperical shape, light rays do not focus on single point and image is blurred
Term
ptosis
Definition
drooping of eye lid
Term
strabismus
Definition
squint or cross eyes, poor convergence
Term
esotrophia
Definition
eyes turn inwards
Term
exotropia
Definition
eyes turn outwards
Term
vertical strabisms
Definition
eye turns up or down
Term
conductive hearing loss
Definition
problem with sound transmitting portions outer or middle ear
Term
treacher collins syndrome
Definition
heredity, underdevelopment of external ear canal and middle ear
Term
ostosclerosis
Definition
progressive condition that occurs as early as late adolescene.... hardening of the ear
Term
tx for conductive hearing loss
Definition
antibiotics, removal of ear wax, placement of tubes
Term
sensorineural hearing loss
Definition
problem or damage to inner ear
chochlear hairs, acoustic nerve or brain stem. not corrected with surgery, need hearing aid or cochlear implants
Term
most common virus associated with sensorineural hearing loss is_____?
Definition
cytomegaly virus ( CMV) most common congenital cause, problems with loudness and distortion of sounds
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