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Block 3 Biochem
High Yield
7
Biochemistry
Pre-School
10/26/2012

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Cards

Term
What labeled AA do we use to determine if gout is from purine overproduction vs. impaired excretion?
Definition
15N-laybeled glycine (forms core of purine)
Term
How does allopurinol inhibition work?
Definition
It is a suicide inhibitor of xanthine oxidase. It is converted to oxypurinol in the process.
Term
Pyrimidine degradation products?
Definition
C----(deamination)--->U--->Beta-alanine, CO2, & NH4+

T ------> Beta-aminoisobutyrate, CO2, & NH4+
Term
AIDS Treatment?
Definition
-uses zidovudine, ZDV, (AKA azidothymidine AZT) which is a dTMP analog
-Works because it is missing the 3' OH group
-Specifically targets reverse transcriptase
Term
RNase P?
Definition
-Functions as a ribozyme
-Used in prokaryotes to cleave transcripts to produce smaller rRNAs, specifically 16S, 25S, & 5S rRNA. (Also some tRNAs)
Term
TB treatment?
Definition
-Uses rifampin of the rifamycin family
-Works by selectively inhibiting bacterial RNA pol
-Can inhibit mit RNA pol in high amounts
Term
p53 deficiency?
Definition
-Rare heritable disorder called Li-Fraumenti syndrome
-Associated with multiple types of tumors
-AUTO DOM because even tho it is a loss of function, there only needs to be one more "hit" to be complete loss of function
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