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Blood and Hematopoiesis
Cell types and derivatives
12
Medical
Graduate
11/17/2012

Additional Medical Flashcards

 


 

Cards

Term
Myeloblast derivatives
Definition

Granulocytes

Neutrophils

  • Most numerous
  • 3-5 lobed nuclei

Basophils

  • Least numerous
  • Histamine and heparin
    • (1) Allergic reactions
  • (2) Viral infections
  • Nucleus obscured by deeply stained basophilic granules (stained by Methylene blue)

Eosinophils

  • Major basic protein-->cytoplasm filled with red granlues stained by eosin
  • Bilobed nuclei
  • (1) Allergic reaction, and (2) parasite
Term
Eosin and Methylene Blue
Definition

Eosin

  • Acidic dye/neagatively charged
  • Stains acidophilic/basic/positively charged structures
  • Redish pink
Methylene Blue
  • Basic dye
  • Stains basophilic structures/acidic sturctures like:
  • DNA, RNA
Term
Hemorrhage indicated by what in PBS
Definition

Normocytic nucleated RBCs

 

Macrocytic if extreme

Term
Reticulocyte count seen using what dye
Definition
Supra-vital-stain
Term
Supra-vital-stain indicates
Definition
Reticulocytes
Term
Corrected reticulocyte count
Definition

(Actual Ht/45) x reticulocyte count

 Divide by 2 if polychromasia present (due to degree of anemia)

Ht= Hbx3

Term
PBS used to indicate
Definition
Size, shape, color, and inclusions of RBCs
Term
Size of RBC related to
Definition
anisocytosis
Term
Abnormal shapes of RBCs
Definition

Microspherocyte- hereditary spherocytosis, hemolytic anemia

 

Sickle cell- homozygous sickle cell

 

Tear-drop cell- bone marrow infiltration/myelofibrosis

 

Schistocyte- [microanglopathic] haemolytic anemia 

Term
Abnormal inclusions of RBCs
Definition

Howell-Jolly bodies- asplenia

Basophilic stippling- Pb poisoning

  • Ferrochelatase inhibition
  • Spleen not working correctly

Cabot's ring bodies- MTs

Heinz bodies- denatured Hb- G6P deficiency

Term
Bone marrow examinations
Definition
Aspirate- take fluid
Biopsy- take bone with it
-ID hypocellular, normal, hypercellular (cancer)
Term
Neutrophilia
Definition
-Infections (appendicitis)
-MI
-Corticosteroids- decrease adhesion, increased release from BM

Shift to left- more band cells

Sepsis or severe inflammation may cause morphological changes:
-toxic granules- abnormal primary granules, darker than normal
-Dohle bodies- dull gray inclusion; patches of dilated RER
-Cytoplasmic vacuoles- phagolysosomes indicating phagocytosis
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