Term
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Definition
| the concentration of iron found in the blood either free or bound to transferrin |
|
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Term
sideroblastic anemia vs.
sideroblast
vs. hemosiderin
vs. hemosiderosis |
|
Definition
sider refers to iron
hemosiderin stores iron
hemosiderosis is iron overdose leading to hemosiderin deposition
sideroblast is a cell without good heme synthesis - so iron accumulates in mitochondria/ferritin granules. |
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|
Term
| what are the three types of granules stored by platelets? |
|
Definition
a) coagulation and adhesion factors
d) (dense bodies) - ADP, serotonin, Ca - to vasoconstrict
y) lysosomes and hydrolytic enzymes - clot breakdown |
|
|
Term
name for RBCs with irregular shapes
- ""irregular sizes |
|
Definition
poikilocytosis
-anisocytosis |
|
|
Term
| which clotting factors are nonenzymatic? |
|
Definition
| i) Tissue Factor, ii) Fibrinogen/Fibrin, iii) Factors VIIIa, Va, XIIIa. |
|
|
Term
thrombomodulin
1) site of production
2) effects |
|
Definition
1) endothelial cells
2) cofactor for thrombin to activate protein C which cleaves factors VIIIa, Va |
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Term
|
Definition
| porphobilinogen synthase (dehydratase) |
|
|
Term
| which steps of heme synthesis are in the mitochondria? |
|
Definition
| ala synthase and ferrocheletase (and the oxidation steps just prior to the ferrocheletase) |
|
|
Term
| enzyme deficiencies lead to pain on light exposure |
|
Definition
| porphyrinogen synthases/oxidases/decarboxylases |
|
|
Term
| lead poisons these steps of porphyrin synthesis |
|
Definition
| ala synthase, porphyrinobiligin synthase, ferrocheletase |
|
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Term
|
Definition
| converts heme to biliverdin using O2, and releases CO and Fe 3+ |
|
|
Term
|
Definition
| uses NADPH to reduce biliverdin to -rubin. (reduces central alkene) |
|
|
Term
| solubilization of bilirubin? |
|
Definition
-transferred to liver in albumin complex
- 2 UDP-glucoses are dehydrogenated to UDP-glucuronates
- these are attached to propionate groups in the middle of the bilirubin |
|
|
Term
which heme breakdown product is secreted in stool?
-in urine (excess breakdown products) |
|
Definition
stercobilin
-stercobilinogen |
|
|
Term
| in which organs does heme oxygenase reaction take place? |
|
Definition
| spleen, liver, bone marrow |
|
|
Term
| catalyzes four pyrroles -> tetrapyrrole |
|
Definition
| hydroxymethylbilane synthase |
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