Term
| contents of blood plasma (3) |
|
Definition
| water, proteins, other solutes |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| normal blood plasma value |
|
Definition
|
|
Term
|
Definition
|
|
Term
| fucking DEFINE: homeostasis |
|
Definition
| keeping many of the constituents of blood plasma within narrow limits |
|
|
Term
| Do RBC have a nucleus? do they have organelles? |
|
Definition
|
|
Term
| what is the structure function relationship in regards to |
|
Definition
| the structure of the RBC allows it to have more S.A. which helps it bind moar O2 |
|
|
Term
| explain how cyanide and CO poisoning works |
|
Definition
| both cyanide and CO bind the iron in heme, which prevents the hemoglobin from carrying 02. our body can't do fucking SHIT with CO or cyanide |
|
|
Term
| explain the entire fucking process of hemopoeisis. where it becomes anuclear |
|
Definition
Hemocytoblast (blood stem cell)>myeloid stem cell>progenitor cells, blast cells.
>Bone marrow> proerythroblast>erythroblast>normoblast (nucleus ejected here)>reticulocyte>circulation>mature RBC |
|
|
Term
| 3 factors needed for erythropoesis (I.V.F) |
|
Definition
| iron, vitamin b12, folic acid |
|
|
Term
| what causes a hemocytoblast to commit to erythrocyte path |
|
Definition
|
|
Term
| what is the lifespan of an RBC |
|
Definition
|
|
Term
| what will stimulato EPO-esis, explain the cycle |
|
Definition
| decreased blood o2>kidney ^regs epo secretion>bone marrow is like wtf ok guess I'll make moar RBCs>moar RBCs released into blood |
|
|
Term
| what is the general definition for anemias |
|
Definition
| decreased 02 to the tissues |
|
|
Term
| 3 reasons why an anemic pt would actually have less o2 in their body |
|
Definition
| overall fewer RBCs, low hemoglobin (iron deficiency anemia), abnormal HB (sickle cell, thalessemia B) |
|
|
Term
| Thalassemia B-abnormal amounts of what? and the RBCs have what 2 qualities? |
|
Definition
| abnormal amounts of HB. the RBCs are MIRCROcytic (small), and hypoCHROMIC (pale). |
|
|
Term
| sickle cell anemia, also what causes it, and what the RBCs "more" |
|
Definition
abnormally shaped blood cells can't move through bloodstream easily, this makes it harder to get o3 to tissue.
cause. what causes it is a wrong AA results in abnormal HBs
the RBCs are moar fragile "hemolytic" |
|
|
Term
| polycythemia, doing what gives this condition |
|
Definition
|
|
Term
|
Definition
| happens when a vessel is damaged |
|
|
Term
|
Definition
| release of chemicals platlets, which leads to platlet aggregation |
|
|
Term
| 5 chemicals favoring plug formation |
|
Definition
1.von willebrand factor
2. serotonin
3. ADP
4.TxA2 (thrombaxane)
5. clotting factors |
|
|
Term
| 2 chems limiting clot formation |
|
Definition
|
|
Term
| draw out clotting pathway after thrombib |
|
Definition
| Thrombin>activates fibrinogen into loos fibrin and XIII into XIIIa>XIIIA actives loose fibrin into STABILIZED fibrin |
|
|
Term
|
Definition
|
|
Term
| what factor comes from activated platelets that is an important cofactor for clotting |
|
Definition
|
|
Term
| intrinsic pathway-intrinsic to what, what gets activated due to contact to what? |
|
Definition
| intrinsic to blood, factor XII is activated due to CONTACT to collagen |
|
|
Term
| extrinsic pathway-requires what from where |
|
Definition
| requires tissue factor from subendothelial cells in vessel wall |
|
|
Term
| common pathway-where do the 2 pathways converge |
|
Definition
| they both converge on the activation of factor x |
|
|
Term
| is the intrinsic or extrinsic pathway activated 1st? |
|
Definition
|
|
Term
| when the extrinsic pathway gets activated what gets activated next on what pathway, what does this allow the intrinsic pathway to do without contact activation and factor XII |
|
Definition
thrombin's positive feedback effects on the intrinsic pathway
it allows the intrinsic pathway to be activated without contact activation and factor XII |
|
|
Term
| liver's role in blood clotting? |
|
Definition
| bile salts>Vitamin K>V.K. in bloof makes clotting factors. |
|
|
Term
|
Definition
1cleaves fibrinogen to fibrin
2activates clotting factors
3stimulates platelet activation |
|
|
Term
|
Definition
| inactivates clotting factor which is done by activating protein c |
|
|
Term
| antithrombin-comes from? weak or strong? made stronger where? |
|
Definition
| liver, weak, stronger with heperain arounf |
|
|
Term
| heparin-what kind of cells are these pretty much |
|
Definition
|
|
Term
|
Definition
| receptor that binds thrombin and activates protein C-->INactivates 2 clotting factors |
|
|
Term
|
Definition
| Tissue plasminogen activator (TPA) |
|
|
Term
| plasmin turns fibrin into? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| thromboembolytic conditions-a clot forms..if it breaks loose its a what? whats it called if its lodged in the lungs |
|
Definition
| clot thats loose is an embolus, in lungs its a pulmonary embolism |
|
|
Term
| if there is a patent foramen ovale..where might an embolism occur? |
|
Definition
| in the arterial systemic system |
|
|
