Term
|
Definition
t12,21
CBFa and ETV6 (25%)
kids |
|
|
Term
|
Definition
Notch1
adolescent males, mediastinal mass
unfavorable: BCR-abl, mll-af4 t4,11 |
|
|
Term
|
Definition
t8,14, or t2,8, t8,22
c-myc (8) and Ig loci, EBV assocation
starry sky
adolescent and young adults |
|
|
Term
| Diffuse large B-cell lymphoma |
|
Definition
bcl6, bcl2, c-myc
t14,18
adults, rapidly growing masses
progressed from follicular
GC type:cd10, bcl6
non-GC:Mum1 (cd10/bcl6-) |
|
|
Term
| extranodal marginal zone lymphoma |
|
Definition
memory b cells
t11,18; t1,14; t14,18
chronic inflammatory disease
malt1 or bcl2 involved both 18, bcl10 (1)
MALT-h.pylori |
|
|
Term
|
Definition
t14,18
bcl2-IgH
older adults
markers:bcl6, cd10, cd5- |
|
|
Term
|
Definition
memory b
older males, pancytopenia, splenomegaly
older adults |
|
|
Term
|
Definition
t11,14 - cyclind-IgH, older males, disseminated aggressive
cd5+, cd23-, cd10-
|
|
|
Term
| multiple myeloma/solitary plasmacytoma |
|
Definition
homing plasma cell
mm- older adults, fxs, hypercal, renal failure
sp- isolated masses- indolent |
|
|
Term
|
Definition
naive/memory b monoclonal, triso12, del 11q, 13q, 17p older adults - indolent
pseudofolicular growth centers in LNs
co-expr cd5/23, low bcr
anemia/thrombocytopenia
unmutated IgH, cd38, zap-70 |
|
|
Term
|
Definition
helper t- htlv-1 provirus, japan, west africa, caribbean, cutaneous lesions, marrow, hypercal
cd4/25+ |
|
|
Term
| Extranodal NK/T-cell lymph |
|
Definition
| ebv, adults, blood vessels, nasal type, asia |
|
|
Term
| mycosis fungoides/sezary syndrome, cutaneous T-cell lymphoma |
|
Definition
| helper t, adults, skin patches |
|
|
Term
| large granular lymphocytic leukemia |
|
Definition
Cd8 T or NK, splenomegaly, neutropenia, anemia
cd8/3/57+ |
|
|
Term
|
Definition
| t15,17, auer rods, PML-RARa fusion, DIC |
|
|
Term
|
Definition
Burkitt, follicular, Large B
bcl6 |
|
|
Term
|
Definition
|
|
Term
|
Definition
b cell laking BCR,
nfKappaB act- bortezomib targets
EBV associated
Nodular sclerosis-classic disease: RS+lacunar in clusters surr by collagen cd15/30+, EBV
mixed cellularity- classic w/diffuse pattern, lymph depletion- advanced, more RS
nodular lymph predominant-L&H cells-smaller than RS, localized, monoclonal, indolent |
|
|
Term
| Anaplasmic Large Cell Lymphoma |
|
Definition
T cell, in kids, hallmark cells with abundant cytopl, cd30
t2,5, anaplasmic lymphoma kinase (alk) |
|
|
Term
|
Definition
mll locus, 11
t8,21 nucleophosmin and CEBPa, inv16 - lower relapse
flt3/itd+, monosomy 7 and 5qdel,t6.9 in adults -higher relapse
11q23-mll gene, intermediate
|
|
|
Term
|
Definition
| granules, auer rods, myeloperoxidase |
|
|
