Term
|
Definition
| cluster of differentiation |
|
|
Term
|
Definition
display of nonpeptide and glycoplipid antigens for T-cell responses
+ dendritic cells
+ bcells
+ Langerhan cells
+ thymocytes
+ monocytes
+ activated T cells
+ epithelial cells |
|
|
Term
|
Definition
Adhesion molecule
signal transduction
earliest Tcell marker
+ Th
+ Tc
+ NK |
|
|
Term
|
Definition
Signal transduction element of T-cell receptor
+ Th
+ Tc |
|
|
Term
|
Definition
Adhesion molecule that binds to class II MHC molecules
signal transduction
+ Th |
|
|
Term
|
Definition
|
|
Term
|
Definition
Adhesion molecule that binds to class I MHC molecules
signal transduction
+ Tc
+ NK (variable) |
|
|
Term
|
Definition
membrane-bound metallopeptidase responsible for cleaving a variety of inflammatory and vasoactive peptides
+ bcell precursors
+ Tcell precursors
+ bm stromal cells
+ neutrophils
+ monocytes
+ keratinocytes |
|
|
Term
|
Definition
Receptor for endotoxin (LPS), activate monocytes or neutrophils to release cytokines (TNF) and up-regulate adhesion molecules when LPS is bound
binds peptidoglycan on gram-positive bacteria, Hsp60, ceramides, modified lipoproteins, and anionic phospholipids
soluble form reported to act as an acute phase protein and may regulate Tcell activation and act as Bcell mitogen
+ monocytes
+ macrophages
+ granulocytes
+ bcells
+ dendritic cells
+ hepatocytes |
|
|
Term
|
Definition
low-affinity receptor for Fc region of IgG
+ NK |
|
|
Term
|
Definition
Part of bcell coreceptor with CD21 and CD81
signal transduction - regulates bcell development, activation and differentiation
+ fDC
+ Bcells |
|
|
Term
|
Definition
ligation activates tyrosine kinase-dependent pathways and may have a role in B-cell proliferation and differentiation
regulates B-lymphocyte activation and proliferation via regulation of transmembrane Ca2+ channel subunit and cell-cycle progression
+ bcells |
|
|
Term
|
Definition
Receptor for:
complement (C3d)
Epstein-Barr virus
+ B cell |
|
|
Term
|
Definition
Receptor for costimulatory B7 molecule on antigen-presenting cells
+ Th
+ Tc |
|
|
Term
|
Definition
Receptor for Fc region of IgG
+ Bcell |
|
|
Term
|
Definition
cell-cell adhesion molecule
participates in inhibition of hem differentiation
+ lymphohematopoietic stem and progenitor cells
+ small-vessel endo cells
+ embryonic fibroblasts |
|
|
Term
|
Definition
Receptor for complement (C3b)
+ bcell |
|
|
Term
|
Definition
signal transduction
+ bcell |
|
|
Term
|
Definition
signal transduction
+ bcell
+ Th
+ Tc
+ NK |
|
|
Term
|
Definition
|
|
Term
|
Definition
binds CD28 and CD152
costimulation of Tcell activation with CD86 when bound to CD28
inhibits Tcell activation when bound with CD152
+ bcell (activated)
+ tcell (activated)
+ resting peripheral blood monocytes
+ dendritic cells |
|
|
Term
|
Definition
major T-cell costim molecule, interacting with CD28 (stimulatory) and CD152/CTLA4 (inhibitory)
+ dendritic cells
+ bcells (memory)
+ germinal center bcells
+ monocytes |
|
|
Term
|
Definition
mediation of apoptosis-inducing signals
+ bcells (activated)
+ tcells (activated)
+ monocytes
+ fibroblasts
+ neutrophils |
|
|
Term
|
Definition
negative regulator of T-cell activation
+ tcells (activated) |
|
|
Term
|
Definition
ligand for CD40, inducer of Bcell proliferation and activation, antibody class switching and germinal center formation
costim molecule and regulator of Th1 generation and fucntion
role in neg selection and peripheral tolerance
+ Tcells (CD4+)
+ basophils
+ platelets
+ monocytes
+ mast cells |
|
|
