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Cerebellum
Neuro
34
Biology
Graduate
11/22/2009

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Term
Ventral aspect of the cerebellum
Definition
Recognize anterior lobe (with vermis)
Posterior lobe (with vermis and tonsil)
Flocculonodular lobe (vermis is known as nodule)...you also have cerebellar peduncle (inf, middle and sup)
Term
Contained within core of cerebellum
Definition
deep cerebellar nuclei
Term
What composes the interposited nuclei?
Definition
emboliform and globose nucleus
Term
What are the layers from to deep to superficial?
Definition
Granule, Purkinge and Molecular
Term
Where does Purkinje terminate?
Definition
Deep nuclei
Term
Purkinje Cell
Definition
Target: deep cerebellar nuclei
GABA (-)
Term
Granule
Definition
Purkinje cell dendrites (via parallel fibers)

Glutamate (+)
Term
Basket Cell
Definition
Purkinje Cell

GABA (-)
Term
Golgi cell
Definition
Granular cell glomerulus
GABA (-)
Term
Stellate Cell
Definition
Purkinje cell dendriates

Taurine (-)
Term
Mossy fiber
Definition
Granular cell glomerulus

Ach (+)

represent all source of input to the cerebellum
Term
Climbing fiber
Definition
Purkinje Cell

Aspartate (+)

Originate from inferior olivary nucleus
Term
Location of various cell types within the cerebellar cortex
Definition
Granule Cell layer: granule cells and golgi cells

Purkinje cell layer: Purkinje cells

Molecular layer: stellate cells and basket cells
Term
Mossy fibers terminate in the ______ while climbing fibers terminate by _______
Definition
granule cell layer, winding around dendrites of Purkinje cells in the molecular layer
Term
Purkinje cells are _______
Definition
the only output of the cerebellar cortex and they are all inhibitory
Term
All cerebellar cortical output is _______
Definition
Inhibitory
Term
What are parallel fibers
Definition
the axons that bifurcate to run at 90 degrees to the dendritic trees of the Purkinje fibers
Term
Glomeruli are better known as what
Definition
The specializations invovling the terminal synapse of mossy fibers (which are +) and golgi cell axon terminals are (-)
Term
Corticopontocerebellar pathway
Definition
Form most areas of the cerebral hemispheres...this pathway is crossed and enters the cerebellum by way of the middle cerebellar peduncle
Term
Vestibulocerebellar pathway
Definition
some vestibular fibers reach the cerebellum directly while the majority synapse in the vestibular nuclei before entering the ipsi cerbellum via the inferior cerebellar peduncle (juxtarestiform body)
Term
Reticulocerebellar pathway
Definition
from the brainstem reticular formation (all levels). This pathway may be crossed but the majority of fibers remain ispi and pass through the inf cerebellar peduncle
Term
Spinal cord
Definition
Anterior spinocerbellar pathway usually crosses in cord and then again back to the side of origin within the sup cerebellar peduncle although some fibers remain ipsi
Term
Mossy fibers make these kinds of connections in the deep cerebellar nuclei.

Hint: glomerular input by mossy fibers are also this way
Definition
Excitatory
Term
Granule cells
Definition
serve as gateway to cortical processing in the cerebellum. The parallel fibers that they have make excitatory connections with Purkinje cell dendritates as well with dendrites of golgi cells, basket cells and stellate cells
Term
A single Purkinje cell can be contacted by as many _______ parallel fibers and a single parallel fiber may pass through and contact the dendrites of as many as _______ Purkinje cells
Definition
1,000,000; 100,000
Term
What axons represent the single source of cerebellar cortical output?
Definition
Purkinje cell axons
Term
How does the cerebellovestibular pathway pass to the vestibular nuclei?
Definition
the inferior cerebellar peduncle
Term
The cerebellonuclear pathway terminates in the?
Definition
deep cerebellar nuclei
Term
What are the three sources of cerebellar input
Definition
Inferior olivary nucleus, climbing fibers, and Purkinje cells
Term
climbing fibers arise from what?
Definition
The contralateral principal (inf) olivary nucleus. They are excitatory and give off axon collaterals to the deep cerebellar nuclei before terminating in the cortex
Term
Parallel fiber collaterals lead to what type of reaction of granule cells and golgi cells?
Definition
excitation of granule cells that lead to excitation of golgi cells
Term
Gated feed-back inhibition
Definition
excitation of golgi cells that will inhibit mossy fiber input to granule cells
Term
Input to the cerebellar cortex is ______ while cortical output is _______
Definition
excitatory; inhibitory
Term
These two make excitatory contacts with the deep cerebellar nuclei
Definition
mossy and climbing fibers
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