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Chapter 12
Hurray Cell Cycle
30
Biology
Undergraduate 1
10/21/2012

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Term
Genome 
Definition

All the DNA in a cell 

Can consist of a single DNA molecule (common in prokaryotic cells) ot a number of DNA molecules (common in eukaryotic cells)

Term
Chromosomes 
Definition
Units of DNA in a cell
Term
Somatic Cells 
Definition
Nonreproductive cells that have two sets of chromosomes 
Term
Gametes 
Definition

Reproductive cells 

Have hals as many chromosomes as somatic cells 

Term
Chromatin
Definition

A complex of DNA and protein that condenses during cell division 

Make up the chromosomes 

Term
Mitotic Spindle 
Definition

An apparatus of microtubules that controls chromosome movement during mitosis 

Assembly begins in the centrosome during prophase 

Term
Sister Chromatids 
Definition
The product of chromosome splitting during cell division 
Term
Centromere 
Definition

The narrow "waist" of duplicated chromosomes where two chromatids are most closely attached

[image]

Term
Mitosis 
Definition
The division of the nucleus [image]
Term
Cytokinesis 
Definition

The division of the cytoplasm 

Is well under way by late telophase 

[image]

Term
Meiosis 
Definition

A variation of cell division that produces gametes 

Yields nonidentical daughter cells that only habe one set of chromosomes, half as many as the parent cell

Term
Mitotic (M) Phase 
Definition
A section of the cell cycle that consists of mitosis and cytokineses [image]
Term
Interphase 
Definition

A section of the cell cycle during which cell growth and copying of chromosomes in preperation of cell division takes place

Takes up approximately 90% of the cell cycle 

Can be divided into 3 subphases:

G1 Phase (first gap) - 

S Phase (synthesis) - 

G2 phase (second gap)

The cell grows during all three phases, but chromosomes are duplicated only during the S phase

 

 

[image]

Term
5 Stages of Mitosis 
Definition

-Prophase 

-Prometaphase - spindle microtubules attach to the kinetochores of the chromosomes and begin to move the chromosomes

-Metaphase - A stage of mitosis at which the chromosomes are all lined up at the metaphase plate

-Anaphase A stage of mitosis during which sister chromatids seperate and move along the kinetochore microtubules toward the opposite ends of the cell 

-Telophase A stage of mitosis during which genetically identical daughter nuclei form at opposite ends of the cell (Cytokinesis is well underway at this point)

Term
Centrosome 
Definition

The microtubule organizing center 

Replicates, forming two centrosomes that migrate to opposite ends of the cell, as spindles of microtubules grow out of them

[image]

Term
Aster 
Definition

A radial array of short microtubules that extends from each centrosome

Is included in the spindle, along with the centrosomes and sprindle microtubules 

[image]

Term
Prometaphase 
Definition
A phase of mitosis, during which spindle microtubules attach to the kinetochores of the chromosomes and begin to move the chromosomes[image]
Term
Metaphase 
Definition

A stage of mitosis at which the chromosomes are all lined up at the metaphase plate

Def: The midway point between the spindles two poles[image]

Term
Anaphase 
Definition

A stage of mitosis during which sister chromatids seperate and move along the kinetochore microtubules toward the opposite ends of the cell 

The microtubules shorten by depolymerizing their kinetochore ends

 [image]

Term
Metaphase Plate 
Definition

The midway point between the spindle's two poles at which the chromosomes are lined up during metaphase 

[image]

Term
Telophase 
Definition
A stage of mitosis during which genetically identical daughter nuclei form at opposite ends of the cell [image]
Term
Cleavage 
Definition

The process of cytonikesis in animal cells

Forms a cleavage furrow 

[image]

Term
Cell Plate 
Definition

What is grown between sperating plant cells in cytokinesis 

[image]

Term
Binary Fission 
Definition

A type of cell duvision used by prokaryotes in which chromosomes replicate (beginning at the origin of replication) and the two daughter cells actively move apart 

Def: The particular location in a genome from which synthesis begins 

Since prokaryotes evolved before eukaryotes, mitosis probably evolved from binary fission 

Certain protists exhibit types of cell division that seem intermediate between binary fission and mitosis[image]

Term

Cell Cycle Control System 

 

Definition

The system that regulates the sequential events of the cell cycle 

Regulated by both internal and external controls

Would appear to be driven by specific chemical signals present in the cytoplasm 

Has specific checkpoints where the cell cycle stops until a go-ahead signal is received 

For many cells, the G1 checkpoint seems to be the most important one

If a cell receives a go-ahead signal at G1, it will usually complete S, G2 and M phases and divide

If a cell does not receive the go-ahead signal, it will exit the cycle, switching into a nondivided state called the G0 phase 

[image]

Term
Cyclins 
Definition

a family of proteins that control the progression of cells through the cell cycle by activating cyclin-dependent kinase (Cdk) enzymes.

[image]

Term
MPF (maturation-promoting factor) 
Definition
A cycline-CDK complex that triggers a cell's passage past the G2 checkpoint into the M phase 
Term
Growth Factors 
Definition
Proteins released by certain cells that stimulate other cells to divide
Term
Density-Dependent Inhibition 
Definition

An external signal that prompts crowded cells to stop growing 

Cancer cells do not exhibit this

[image]

Term
Anchorage Dependence 
Definition

Cells must be attached to a substratum in order to divide

Cancer cells do not exhibit this

[image]

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