Term
(Alkylating agents) (Antineoplastic agents) (ch.14) altretamine,carboplatin,carmustine,chlorambucil,cisplatin,
cyclophosphamide,dacarbazine,ifosfamide,lomuustine,
mechlorethamine,melphalan,streptozocin,thiotepa |
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Definition
| are used to interfere with the normal process of cell division.this effect occurs in both malignant and normal cells although malignant cells seem to be effected much more by the medications. |
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Term
| altretamine(Hexalen) Alkylating Agents (ch.14) |
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Definition
| Used for palliative treatment of patients with persistent or recurrent ovarian cancer. |
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Term
| busulfan (Busulfex) (Myleran) Alkylating Agents (Ch.14) |
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Definition
| Used in chronic myelogenous leukemia;may produce leukopenia,anemia,thrombocytopenia,hyperpigmentation of skin,and cataracts.usually adult dose 4-8mg/day PO. |
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Term
| carboplatin(Paraplatin) Alkylating Agents (ch.14) |
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Definition
| Used in ovarian carcinoma.Usual adult dose 360mg/m2 iv on day 1 every 4 weeks |
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Term
| carmustine(BiCNU) Alkylating Agents (ch.14) |
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Definition
| used in patients with brain tumors,Hodgkins disease,and multiple myeloma;may produce leukopenia,thrombocytopenia,azotemia,nausea,and vomitting;causes burning at injection site.usual adult dose 360 mg/m2 IV. |
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Term
| CHAPTER 14 Antineoplastic Agents Alkylating Agents |
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Definition
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Term
| Gliadel wafers Alkylating Agents Antineoplastic Agent) (ch.14) |
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Definition
| wafer inserted into cavity after surgery.Up to 8 wafers at a time may be used.Indicated in newly diagnosed pt.s with high grade malignant glioma as an adjunct to surgery and radiation;also indicated in recurrent glioblastoma mutiforme pts. as an adjunct to surgery;provideslocalized delivery of chemotherapy directly to site of tumor-the FDA-approved brain cancer treatment capable of doing so. |
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Term
| chlorambucil(Leukeran) Alkylating Agents (ch.14) |
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Definition
| Used in Hodgkins disease,chronic lympocytic leukemia and malignant lymphomas;may produce hyperuricemia and bone marrow depression>usual adult dose 0.1-0.2 mg/kg/day Po |
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Term
| cisplatin(Platinol-AQ) (Alkylating Agents) (Antineoplastic Agents) (ch.14) |
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Definition
Used in advanced bladder cancer and some metastatic testicular and ovarian tumors;may produce nausea,vomiting,leukopenia,thrombocytopenia,ototoxicity,
and nephrotoxicity.usual adult dose 50-70mg/m2 IV for bladder cancers.give 75-100mg/m2for ovarian tumorsand 20mg/m2for testicular tumors |
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Term
| cyclophosphamide(Cytoxan)(Neosar) (Alkylating) (Antineoplastic Agents) (ch.14) |
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Definition
Used in hodgkins disease,leukemia,carcinoma of ovary and breast,malignant lymphomasmulitiple melanoma and neuroblastoma;may produce anorexia,nausea,vomiting,diarrhea,cystitis,alopecia,
leukopenia,thrombocytopenia,or anemia. |
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Term
| dacarbazine(DTIC-Dome) (Alkylating) (Antineoplastic agents) (Ch.14) |
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Definition
| Used in metastatic malignant melanoma,Hodgkins disease. |
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Term
| ifosfamide(Ifex)(Ifex-Mesnex) (Antineoplastic agents) (Alyklating Agent) (ch.14) |
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Definition
| Used in testicular cancer. Give 1.2 g/m2/day |
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Term
| lomustine(CeeNu) Alkylating agent) (Antineoplastic Agent) (ch.14) |
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Definition
Used in Hodgkin's disease,some brain tumors;may produce nausea,vomiting,alopecia,anemia,leukopenia,
thrombocytopenia,usual adult dose 100-130 mg/m2 Po |
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Term
mechlorethamine(Mustargen)
(Alkylating Agent)
(Antineoplastic Agent)
(ch.14) |
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Definition
| Used in Hodgkins disease,bronchogenic carcinoma,and lymhosarcoma;may produce nausea,vomiting,jaundice,alopecia,skin rash,diarrhea,lymphocytopenia,granulocytopenia,and trombocytopenia,usual adult dose 0.4mg/kg IV as a total dose for a course of therapy.May be given as a single dose orr divide. |
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Term
melphalan(Alkeran)
(Alkylating agents)
(Antineoplastic agent)
(ch.14) |
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Definition
| Used in carcinoma of ovary and for multiple myeloma;may produce nausea,vomiting,skin rash,and bone marrow depression,usual adult dose 6-10 mg/day PO |
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Term
| streptozocin(Zanosar) (Alkylating agent) Antineoplastic agent) (ch.14) |
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Definition
| Used in carcinoma of the pancreas;may produce severe nausea,vomitting,and renal toxicity.usual adult dose 500-1000 mg/m2 IV |
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