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microscopic vessels that usually connect arterioles and venues - permit exchange of nutrients and waste -found near very cell in body -distribution varies with metabolic activity in the tissue |
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Structures that lack capillaries |
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cornea, lens, epithelium, and cartilage |
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flow of blood through capillaries - regulated by smooth muscle sphincters in the walls |
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composed of single layer of cells (endothelium) and a basement membrane |
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Capillary network throughout the tissues |
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increase surface area- allow rapid exchange of large quantities of materials |
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rings of smooth muscle fibers that regulate blood flow through true capillaries |
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continuous, fenestrated, sinusoids |
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plasma membrane forms complete tube interrupted by small intercellular gaps - found in muscle and connective tissue |
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"window" plasma membrane has small pores - choirod plexus, villi, kidneys |
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large fenestrations and gaps in the basement membrane - red bone marrow, liver, and spleen |
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little veins- formed from the union of several capillaries -merge to form veins -drain blood from capillaries |
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consist of same three tunics as arteries- but thinner -less elastic tissue and smooth muscles -contain valves to prevent back flow of blood |
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veins with very thin walls with NO smooth muscle to alter their diameters - coronary sinus of the heart |
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weak valves can lead to this- causes=congenital, standing, pregnancy, aging |
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union of branches of two or more arteries supplying the same region- alternate blood pathways to get to the same region - collateral route of blood (alternate) |
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blockage in arteries that dont have anastomoses (end arteries) - arteries die |
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Largest portion of the blood is in systemic veins and venules (64%) - collectively called ___ - they store blood and can move it if the body needs it |
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diffusion, transcytosis, bulk flow |
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most important method of capillary exchange- 0c, C02, flucose, amino acids, hormones, and others diffuse down concentration gradient -small proteins diffuse -plasma solutes diffuse across capillary walls -brain-blood-brain barrier exists |
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moves large lipid insoluble molecules across the capillary walls by enclosing substances within tiny vesicles that enter cells by endocytosis and exit by exocytosis -insulin |
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-interstitial fluid & blood --specific to capillary beds passive flow of water and solutes in one direction driven by pressure (up pressure to down pressure) -more important for determining the relative volumes in the blood stream and the interstitial fluid space -dependent upon hydrostatic and osmotic pressure |
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Starlings law of capillaries |
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balance between two filtration pressures of moving material out and bringing it back in -hydrostatic pressures and osmotic pressures |
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between ateriole and venules - certain amount of fluid will filter out of the begining capillary and 85% of that fluid will be reabsorbed |
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C.O./ min - mL/min -how much of the cardiac output is distributed to a tissue depends on the interplay of the pressure differences that drives the blood flow and the resistance to blood flow through that tissue |
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is the pressure exerted on the walls of a blood vessel |
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Factors that affect blood pressure |
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cardiac output=increase blood volume=increase viscosity=increase resistance=increase elasticity of arteries=maintains bp rather than increase |
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the opposition to blood flow as a result of friction between blood and the walls of blood vessels |
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