Term
| Viruses that cause Viral Hepatitis? |
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Definition
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Term
| What are the virus types for HAV, HBV,HCV,HDV,HEV ? |
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Definition
| ALL are RNA, except HBV, which is DNA |
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Term
| Definition of undetectable serum HBV DNA, and HCV RNA |
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Definition
Concentration of < 15 IU/ml
this is one of the goals of therapy |
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Term
| What Viruses are there specific vaccines for ? |
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Definition
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Term
| How long is the HAV vaccine effective ? |
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Definition
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Term
| Acute Viral Hepatitis Definition & treatment |
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Definition
Definition: viral hepatic infection present for <6 months
Avoid alcohol until normalization, stop all hepatotoxic drugs. If has prolonged INR >1.4 administer vitamin K. Patients often become constipated due to encephalopathy and require lactulose.
If it is HCV RNA, that has persisted for 12 weeks, consider treatment with peginterferon. |
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Term
| If a patient has acute viral hepatitis, with HCV RNA > 12 weeks, what can be administered? |
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Definition
| If it is HCV RNA, that has persisted for 12 weeks, consider treatment with peginterferon. |
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Term
| Definition of Chronic Viral Hepatitis |
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Definition
Definition of Chronic Viral Hepatitis:
Lasting longer than 6 months |
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Term
| DOC vs. Chronic Hepatitis B |
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Definition
Chronic Hepatitis B
DOC: Peginterferon alfa |
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Term
Other Drugs that can be used against Chronic HBV: Lamivudine, Entecavir, Adefovir
Which is associated with highest rates of resistance, but improved outcomes in patients with decompensated cirhosis?
Lowest rates of resistance? |
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Definition
Other Drugs that can be used against Chronic HBV: Lamivudine, Entecavir, Adefovir
Which is associated with highest rates of resistance, but improved outcomes in patients with decompensated cirhosis:
Lamivudine
Lowest rates of resistance: Entecavir |
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Term
Treatment of Chronic Hepatitis C
How long should treatment last for the different genotypes? |
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Definition
Peginterferon alfa + ribavirin (peginterferon alfa monotherapy if cannot tolerate, or contraindicated to ribavirin)
*Use peginterferon alfa for both chronic and acute HCV RNA (if acute > 12 weeks)
HCV genotype 1: 48 weeks, genotypes 2 & 3: 24 weeks |
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Term
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Definition
| Common SE of Ribavirin is Hemolytic anemia, and its often dose limiting |
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