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Details

Chronic Myelogenous Leukemia and other Myeloproliferative
Clinical Medicine Test 5
9
Medical
Graduate
11/05/2010

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Cards

Term
What is CML caused by?
Definition
Philadelphia chromosome translocation seen in 95%
Term
What is the most common physical finding in CML?
Definition
splenomegaly
Term
What WBC is seen in CML?
Definition
> 100x109 /L
Term
chronic phase usually changes to what in CML?
Definition
blastic phase
Term
What med has revolutionized treatment in CML and how does it work?
Definition
1) imatinib
2) blocks tyrosine kinase activity
Term
What Px is a common finding w/polycythemia vera?
Definition
1) ruddy cyanosis
2) hepatosplenomegaly
3) conjunctival plethora
4) HTN
Term
What is the platelet levels to diagnosis essential thrombocythemia?
Definition
> 600x109 /L
Term
What is the drug of choice for essential thrombocythemia?
Definition
Hydroxyurea
Term
Charcteristic splenomegaly, extramedullary hematopoiesis, and bone marrow suppresion is seen in what?
Definition
Idiopathic myelofibrosis
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