Term
|
Definition
Persistant painless lymphadenopathy
majority asymptomatic
Const Symp-- fever, night sweats, wt loss-- 25-30%
Pel-Ebstein Fever
Generalized Pruritis
Pain in lymph post-alcohol
herpes-zoster/mycofungal infections
Splenomegaly-- more in kids |
|
|
Term
| Hodgkin's Lymphoma distinctive cells |
|
Definition
| Reed-sternberg cells- OWL EYES |
|
|
Term
|
Definition
Bimodal Age distribution
M>W
Whites>AA
Younger in India-- EBV |
|
|
Term
|
Definition
CBC, ESR, Serum Chemistry, LDH Level, Immunophenotyping, Lymph node histopathology
CXR, CT, PET, Gallium |
|
|
Term
| Hodgkin's Diagnostic Interpretations |
|
Definition
Elevated ESR
Elevated LDH
Reed-sternberg cells
most cells are normal lymphoid, plasma cells, monocytes, and eosinophils |
|
|
Term
|
Definition
Combo Chemo most patients
-MOPP
-ABVD
-BEACOPP
Relapse after radiation-- chemo
Chemo + Radiation for bulky mass
Chemo for earlier stages in testing... |
|
|
Term
|
Definition
Fever, anemia, infections
marked lymphadenopathy-- recurring
Const sympt-- fever, night sweats, wt loss (B sympt in high grade)
hepatosplenomegaly |
|
|
Term
| Non-Hodgkin's Diagnostic Interpretations |
|
Definition
No Reed-sternberg cells or eosinophils
cytopenias
Chromosomal translocations
Waldeyer's ring-- GI
PBS normal but some lymphomas in leukemic phase
Serum LDH increased
CXR-- mediastinal mass |
|
|
Term
| Non-Hodgkin's distribution |
|
Definition
common, 4th ranked hematology cancer
1:46M:56W (3:1, M:W)
Elderly
55-75 median age |
|
|
Term
| Non-Hodgkin's Diagnostic test |
|
Definition
| CBC, Chemistries, urinalysis, CT, Bone marrow biopsy/aspirate, lumbar puncture, PBS, Serum LDH, CXR |
|
|
Term
|
Definition
Chemo + Alkylating agents: Chlorambucil
+ CVP
Fludarabine
Rituximab-- salvage therapy
Short course chemo + CHOP + localized radiation
Chemo + CHOP for 6-8 cycles
CHOP + Rituximab for elderly |
|
|
Term
| allogenic transplantation |
|
Definition
| used for some patients with aggressive low grade lymphomas |
|
|
Term
|
Definition
| for patients with limited indolent disease (lymphoma) |
|
|
Term
| Multiple Myeloma Treatment that's potentially curable |
|
Definition
| potentially Curable w/High dose chemo (BM/SC transplant) |
|
|
Term
| Multiple Myeloma symptoms |
|
Definition
20% asymptomatic
anemia
bone marrow failure
renal failure
recurrent infections
hyperviscosity syndrome
Proximal renal tubular acidosis |
|
|
Term
| Multiple Myeloma Epidemiology |
|
Definition
average age 65
Males>Females
Blacks 2x> Whites
5 year survival-- 25-30%
Medial survival-- 30-36 mos |
|
|
Term
| Multiple Myeloma Diagnostic Interpretations |
|
Definition
Thrombocytopenia
Neutropenia
Amyloidosis
Lytic lesions
Decreased bone density
hypercalcemia
RBC normal with Rouleau formation
Neutrophil/Platelet normal AT FIRST
Proteinuria-- Bence Jones Proteins
ESR Elevated
PBS-- plasma cells rarely visible
SPEP-- Paraprotein
IgG Production
Phosphaturia, glycosuria, uricosuria, aminoaciduria
BM biopsy w/5-100% infiltrate plasma cells
Deletion of 13q chromosome |
|
|
Term
| Multiple Myeloma diagnostic testing |
|
Definition
Bone X-rays
IEP, Urine IEP
SPEP
Bone marrow biopsy
PBS
ESR |
|
|
Term
| Multiple Myeloma Treatments |
|
Definition
-Combo Chemo + VAD
-Thalidomide and thalidomide derivatives and experimental agents CC-5013 and PS-341
-Thalidomide, berexomib (PS-341, Velcade), and the experimental agent CC-5013 (Revimid)
-Mobilization, hydration, and bisphosphonates for hypercalcemia
-Bisphosphonates (eg, pamidronate, 90 mg, or zoledronate, 4 mg IV Q month) to reduce pathological fractures |
|
|
Term
| Multiple Myeloma chronic treatment |
|
Definition
-Autologous stem cell transplantation in patients aged <70
-Autologous transplantation useful in relapse if disease still chemotherapy sensitive
-Allogeneic transplantation potentially curative, but role limited by unusually high mortality rate |
|
|
Term
|
Definition
5/100,000 people
most common pediatric cancer
peak 2-6 years
Males, Whites, Jews |
|
|
Term
| ALL Diagnostic interpretations |
|
Definition
leukemic cells in BM
Anemia, thrombocytopenia, neutropenia
WBC vary
>25% leukemic blast cells
hyperuricemia
hypomagnesemia
hypocalcemia/hypercalcemia
low serum immunoglobulins |
|
|
Term
|
Definition
fatigue, pallor, bleeding, infection (respiratory, dental, perirectal, sinus, UTI)
Hepatosplenomegaly
testes enlargement
mimic RA
CNS-- vomiting, headache, papilledema, neck stiffness, cranial nerve palsy |
|
|
Term
|
Definition
Radiation therapy
TBI-- for BMT
Chemo
BMT |
|
|
Term
|
Definition
5x more than ALL
equally at all ages, slightly more common >50
-elderly 19/100,000
80% of adult leukemia
4.6(M):3.0(W)/100,000 |
|
|
Term
|
Definition
increased fatigue
decreased exercise tolerance
excess bleeding
fevers/recurrent infections
headache, vision changes
early satiety
history of cancer/smoking
petechiae, purpura
splenomegaly |
|
|
Term
| AML diagnostic interpretations |
|
Definition
neutropenia
Abn Blood count-- thrombocytopenia
leukocytosis, anemia
Chromosomal abnormality
Auer rods
BM w/30% blast cells |
|
|
Term
|
Definition
M3-- retinoic acid (vit a derivative)
combo chemo, radiation, BMT |
|
|
Term
| CLL diagnostic interpretations |
|
Definition
| Chromosomal deletion at 13q14 |
|
|
Term
|
Definition
most common leukemia
increase with age
median 65, rare under 35
Men>Women
White>blacks
uncommon in asia |
|
|
Term
|
Definition
new lymphadenopathy
fatigue
frequent infections
bone pain
excessive sweating
generalized pruritis- after shower
easy bruising
splenomegaly |
|
|
Term
| CLL diagnostic interpretations |
|
Definition
Lymphocytes >10,000
^ leukemic cells in BM, blood, LN, spleen
lymphocytosis
anemia, thrombocytopenia
CD5/23 (30% have 38) |
|
|
Term
|
Definition
no optimal treatment
Chemo for thrombocytopenia/anemia
Radiation palliative care for localized tumors
Splenectomy for cytopenia |
|
|
Term
| CML diagnostic interpretations |
|
Definition
Philadelphia chromosome
anemia, thrombocytopenia
leukocytosis
myeloblasts, promyelocytes, reticulocytes
Serum B12 elevated
Decreased LAP score
BM-- granulocytic/megakaryocytic hyperplasia
Left shift on CBC |
|
|
Term
|
Definition
20-30% of leukemias
Rare in children, uncommon before 21
Peaks mid 40's
Males slightly more common |
|
|
Term
|
Definition
malaise, fatigue, sweating, heat intolerance, easy bruising
wt loss, peripheral leg edema
splenomegaly-- progressive/painful
LUQ discomfort
early satiety
fever, bone pain, and wt loss from blast crisis |
|
|
Term
|
Definition
Imatinab (Gleevec) 400mg/d PO
Radiation-- TBI/spleen
Chemo
SCT |
|
|
Term
| Polycythemia Vera Epidemiolgoy |
|
Definition
2/100,000 people
increase with age
median 60 yrs old
peak 50-70 yrs old
men 2x> women (except during reproduction age) |
|
|
Term
| Polycythemia Vera Symptoms |
|
Definition
neurologic: vertigo, tinnitus, headache, visual disturbances, transient ischemic attack
Venous/arterial thrombosi: Hempatic ven thrombosis/Budd-Chiari Syndrome, MI, stroke, peripheral vascular disease
Massive splenomegaly
Aquagenic pruritis
Easy bruising
Erythromelalgia: burning, throbbing, reddness of LE/hands; feet/lower legs flushed and warm; acral parasthesis |
|
|
Term
| Polycythemia Vera Diagnostic interpretations |
|
Definition
Elevated red cell mass (>36M, >32W)
leukocytosis
thrombocytosis
LAP increased
B12 increased
Normal O2 saturation
CBC: elevated Hgb, Hct, RBC #
MCV decreased
Platelet/Leukocyte elevated
Plasma EPO LOW
Granulocyte alkaline phosphate level elevated
tisomy 8 or 9
20q- |
|
|
Term
| Polycythemia Vera treatments |
|
Definition
phlebotomy
maintain hgb at 14M and 12W
Others:
hydroxyurea
interferon a
allogenic BM for young patients |
|
|
