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Definition
| Fibrinogen- substrate for thrombin and precursor of fibrin. it is a large globulin protein. Its function is to be converted into an insoluble protein and then back to soluble components. |
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Definition
| Prothrombin- precursor to thrombin in the presence of CA. It is converted to thrombin. It in turn stimulates platelet aggregation and activates cofactors protein C and factor XIII. It is vitamin K dependent |
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Term
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Definition
| Thromboplastin- Tissue factor activates factor VII when blood is exposed to tissue fluids |
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Term
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Definition
| Ionized Calcium- This active form of calcium is needed for the activation of thromboplastin and for conversion of prothrombin to thrombin |
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Term
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Definition
| Proaccelerin or labile factor- consumed during clotting and accelerates the tranformation of prothrombin to thrombin. Vitamin K dependent factor. 20% found on platelets |
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Definition
| Proconvertin or Stable Factor- This is actived by tissue thromboplastin, which in turn activates factor X. It is vitamin K deptndent |
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Term
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Definition
| Antihemophilic- used for the cleavage of factor X-Xa by IXa. deficient in hemophilia A. not synthisized exclusively by liver. genetically controlled by X chromosome. Forms complex with vWF |
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Term
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Definition
| plasma Thromboplastin component- component of the thromboplastin generating system. it influences amound as opposed to rate. it is deficient in hemophilia B also known as christmas disease- sex linked and vit K dependent |
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Term
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Definition
| stuart-prower- final common pathway merges to form conersion of prothrmbin to thromib activity also related to factors VII and IX. it is vit K dependent and cn be indepently activted by russells viper venom |
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Term
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Definition
| Plasma thromboplastin antecedent. Essential to intrinsic thromboploastin generating of the cascade- jewish population- risk of potoperative hemorrhage |
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Definition
| Hageman factor- this surface contact factor is activated by collagen. Patients do not bleed but have a tendency to thrombosis |
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Definition
| Fibrin Stabilizing Factor-In the presence of calcium this transaminase stabilized polymerized fibrin monomers in the initial clot. This is the only factor that is not found in circulating plasma. |
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Term
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Definition
| FACTORS I,V, VIII, and XIII they are consumed during coagulation |
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Term
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Definition
| factors II, VII, IX and X are all dependent on viatmin K. This group is stable and remains preserved in stored plasma |
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Term
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Definition
| Factor XI, XII prekalikrein, and HMWK.. moderately stable and not consumed during coagulation |
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Term
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Definition
| APTT (Heperin therapy) contact activation pathway |
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Term
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Definition
| PT (coumadin therapy) tissue factor pathway |
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