Term
What is the most common connective tissue disease? |
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Definition
systemic lupus erythematosus |
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Term
What is the second most common connective tissue disease? |
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Definition
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Term
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Definition
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Term
What three general factors determine lupus? |
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Definition
genetic
enviornmental
immunologic |
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Term
What type of hypersensitivity is lupus? |
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Definition
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Term
What are the four most common causes of death in a lupus patient? |
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Definition
Renal Failure
Infection
CNS complications
Coronary artery disease |
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Term
What occurs to the small vessels in lupus? |
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Definition
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Term
What disease presents with palpable purpura and why? |
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Definition
Lupus due to the small vessel vasculitis |
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Term
What characteristic finding of lupus is sensitive to light? |
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Definition
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Term
What is the difference between the joint disease of lupus and rheumatoid arthritis? |
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Definition
RA is destructive synovitis
Lupus in non-destructive |
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Term
What does the synovitis in lupus cause? |
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Definition
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Term
What is the most common manifestation of lupus? |
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Definition
symmetric polyarthralgias |
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Term
What disease presents with serous membrane inflammation? What are the common sites? |
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Definition
Lupus
Pericarditis
Pleuritis
Peritonitis |
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Term
Why do lupus patients have an increase risk of Coronary Artery Disease? |
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Definition
b/c they have accelerated artherosclerosis |
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Term
What disease presents with antiphospholipid antibody syndrome and what does it cause?
What disease does this make this disease often get confused with? |
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Definition
Lupus
Anitphospholipid antibody syndrome causes and increase in coagulation
Syphilis |
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Term
What are the most diagnositic tests for lupus? (2) |
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Definition
dsDNA
Smith antigen (small nuclear ribonucleoprotien) |
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Term
45 y/o Female presents with arthralgia in both knees. She has also noticed a rash under her eyes. In addition, she notes that when she is in the sun, this rash often is painful. What is the most likely diagnosis? What tests would you want to order? |
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Definition
Systemic Lupus erythematosus
order smith antigen and dsDNA test |
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Term
What disease presents with scaring of the skin and organs due to narrowing of vessels? |
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Definition
systemic sclerosis (scleroderma) |
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Term
What are the two categories of scleroderma? What are the general characterisitics of both? |
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Definition
diffuse: rapid progression, generalized skin lesions, organ involvement
limited- less skin involved, slower progression, CREST |
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Term
What does CREST stand for? |
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Definition
Calcinosis of skin
Reynauds phenomenum
Esophageal dysfunction(dysphagia, large diverticuli)
Sclerodactyl
Telengiectasia
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Term
What disease presents with antibody to centrosome? |
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Definition
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Term
What is true of the skin in scleroderma? |
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Definition
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Term
Where are the most likely locations (2) that scleroderma will present in skin? |
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Definition
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Term
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Definition
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Term
What disease presents with stone facies or mask like face? |
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Definition
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Term
What is Reynauds Phenomenon? |
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Definition
vasoconstriction leading to ishemia and thus causing triple color change
white to blue to red |
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Term
What are the two most common GI manifestations of Scleroderma? |
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Definition
dysphagia
large mouth diverticula |
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Term
What is the most likely cause of death in scleroderma? |
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Definition
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Term
What is sclerodermal renal crisis? |
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Definition
ischemia in kidney leads to renal hypertension and eventually renal failure |
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Term
What connective tissue diseases have risks of malignancy? |
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Definition
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Term
What disease is associated with B-cell lymphoma risk? |
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Definition
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Term
What is keratoconjunctivitis sicca? |
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Definition
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Term
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Definition
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Term
What occurs to lacrimal and salivary glands in Sjogren's Syndrome? |
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Definition
they atrophy, fibrosis, and eventually destruct |
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Term
What two antibodies are seen in Sjogren's? |
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Definition
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