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Activate infected macrophages
Provide help to B cells for Ab production |
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Provide help to B cells for Ab production, especially switching to IgE |
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Enhance neutrophil response
Promote barrier integrity (skin, intestine) |
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B cell help isotype switching
Ab production |
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Suppress T cell responses |
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Definition
IL-2, IFN-g, LT (TNF-b, LT) |
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Macrophages: activate, increase MHC I and II |
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Definition
Macrophages: activation, induce NO production (increased phagocytic capacity) |
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Definition
B cells: activation, growth, IgG1 and IgE, increase MHC II
T cells: growth, survival |
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Eosinophil: growth and differentiation |
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B cells: increases MHC II
T cells: inhibitory cytokine, inhibits Th1 differentiation
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Macrophages/dendritic cells: inhibits activation
Turns off immune response |
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Neutrophils: stimulates recruitment
Other somatic cells: stimulates fibroblasts and epithelial cells to secrete chemokines (attracts more neutrophils and macrophages, enhances inflammatory response) |
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Causes fever, acute inflammation
Activates endothelium to express adhesion molecules; induces chemokine secretion to recruit leukocytes |
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Definition
Causes fever, secreted by helper T cells |
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Definition
Major chemotactic factor for neutrophils |
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Definition
Produced by Th2
Helps with IgE production |
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IL-4 and antibody production |
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Definition
induces: IgG1, IgE
inhibits other antibodies from forming
released from Th2 |
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IL-5 and antibody production |
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Definition
augments IgA production
inhibits the other antibodies from forming
released from Th2 |
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IFN-g and antibody production |
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Definition
induces IgG3, IgG2a
inhibits the others from forming
released from Th1 |
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TGF-b and antibody production |
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Definition
induces IgG2b, IgA
inhibits the others from forming
released from Th1 |
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