Term
Fatty acid synthesis requires _____ as its precursor and this molecule. |
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Definition
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Term
Can acetyl CoA cross the mitochondrial membrane?
What transport system does it use? |
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Definition
No, uses tricarboxylate transport system (malate shuttle). |
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Term
Citrate is broken down to what two molecules?
Where?
What enzyme? |
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Definition
OAA and acetyl CoA
cytosol
ATP citrate lyase |
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Term
When is fatty acid synthesis initiated?
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Definition
When citrate is exported into cytoplasm. |
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Term
Review the Malate transport pathway.
What is the purpose? |
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Definition
Shuttle acetyl CoA to the cytosol and regenerate OAA and acetyl CoA |
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Term
OAA is reduced to malate by what enzyme? |
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Definition
malate dehydrogenase and NADH |
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Term
Is pyruvate permeable to the inner mitochondrial membrane? |
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Definition
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Term
Fatty acid biosynthesis combines _____ ____ to form ______. |
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Definition
8 2-C fragments from acetyl CoA to make palimate |
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Term
What are the two steps in fatty acid synthesis? |
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Definition
1. Acetyl CoA carboxylase (irreversible, biotin, ATP)
2. Fatty acid synthase |
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Term
Acetyl CoA carboxylase is ______ by ______.
1. citrate -- stimulated
2. epi, glucagon, NE -- inhibited
insulin -- stimulated
3. malonyl Co-A -- stimulate |
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Definition
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Term
What does palmitoyl CoA do to Acetyl CoA carboxylase? |
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Definition
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Term
Phosphorylated Acetyl CoA Carboxylase is in the ____ form, done by this hormone. |
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Definition
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Term
Palimate is activated in this form. |
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Definition
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Term
T/F Elongation of palmitoyl CoA (activated) can occur is most tissues.
T/F Desaturation " ". |
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Definition
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Term
Two places elongation can occur in a cell. |
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Definition
ER (malonyl CoA, NADPH)
Mitochondria (acetyl CoA, NADH, NADPH) |
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Term
Which elongation process resembles de novo fatty acid synthesis?
Which elongation process is essential the opposite of B oxidation? |
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Definition
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Term
Synthesis of TAGs occurs in which two tissues? |
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Definition
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Term
What is the clinical importance of adipose lacking glycerol kinase? |
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Definition
Can only make f'a's when glucose is available using DHAP (ie, in fed state) |
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