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De novo fatty acid synthesis
L3
19
Biochemistry
Graduate
11/13/2010

Additional Biochemistry Flashcards

 


 

Cards

Term
Fatty acid synthesis requires _____ as its precursor and this molecule.
Definition

acetyl CoA

 

NADPH

Term

Can acetyl CoA cross the mitochondrial membrane?

 

What transport system does it use?

Definition
No, uses tricarboxylate transport system (malate shuttle).
Term

Citrate is broken down to what two molecules?

 

Where?

 

What enzyme?

Definition

OAA and acetyl CoA

 

cytosol

 

ATP citrate lyase

Term

When is fatty acid synthesis initiated?

 

Definition
When citrate is exported into cytoplasm.
Term

Review the Malate transport pathway.

 

What is the purpose?

Definition
Shuttle acetyl CoA to the cytosol and regenerate OAA and acetyl CoA
Term
OAA is reduced to malate by what enzyme?
Definition
malate dehydrogenase and NADH
Term
Is pyruvate permeable to the inner mitochondrial membrane?
Definition
Yes
Term
Fatty acid biosynthesis combines _____ ____ to form ______.
Definition
8 2-C fragments from acetyl CoA to make palimate
Term
What are the two steps in fatty acid synthesis?
Definition

1. Acetyl CoA carboxylase (irreversible, biotin, ATP)

2. Fatty acid synthase

Term

Acetyl CoA carboxylase is ______ by ______.

 

1. citrate -- stimulated

2. epi, glucagon, NE -- inhibited

insulin -- stimulated

3. malonyl Co-A -- stimulate

Definition
Term
What does palmitoyl CoA do to Acetyl CoA carboxylase?
Definition
inhibit
Term
Phosphorylated Acetyl CoA Carboxylase is in the ____ form, done by this hormone.
Definition
inactive, glucagon
Term
Palimate is activated in this form.
Definition
Palmitoyl CoA
Term

T/F Elongation of palmitoyl CoA (activated) can occur is most tissues.

 

T/F Desaturation " ".

Definition

T

 

T

Term
Two places elongation can occur in a cell.
Definition

ER (malonyl CoA, NADPH)

 

Mitochondria (acetyl CoA, NADH, NADPH)

Term

Which elongation process resembles de novo fatty acid synthesis?

 

Which elongation process is essential the opposite of B oxidation?

Definition

ER

 

Mitochondria

Term
Synthesis of TAGs occurs in which two tissues?
Definition
Liver and adipose
Term
What is the clinical importance of adipose lacking glycerol kinase?
Definition
Can only make f'a's when glucose is available using DHAP (ie, in fed state)
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