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Development lecture 1
Flash Cards from Medical school human development course
38
Other
Graduate
10/07/2010

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Term
Initial progenitor of all musculoskeletal tissues
Definition
Mesenchyme
Term
embryonic tissue precursor for vertebrae and ribs
Definition
scleratome of somites
Term
embryonic tissue Precursor of sternum
Definition
somatic mesoderm
Term
embryonic tissue Precursor of skull
Definition
either paraxial mesoderm (head mesoderm and occipital somites) or Neural Crest (ectoderm)
Term
embryonic tissue Precursor of appendicular skeleton
Definition
somatic mesoderm
Term
embryonic tissue precursor for skeletal muscle
Definition
Myotome tissue (epaxial and hypaxial) of somites and paraxial mesoderm of head
Term
embryonic tissue precursor for smooth muscle
Definition
Mostly splanchnic mesoderm, but some somatic mesoderm.
Term
embryonic tissue precursor for cardiac muscle
Definition
Splanchnic mesoderm
Term
Where are all skeletal muscle precursors are derived from
Definition
paraxial mesoderm
Term
CBFA-1
Definition
encodes transcription factors that tell a cell to become an osteoblast and form bone
Term
Sox-9
Definition
Tells cell to become chondroblast and form cartilage
Term
where is the centrum of the forming vertebrae derived from?
Definition
loose portion of the PERINOTOCHORDAL sheath
Term
where are the neural arches of the forming vertebrae derived from?
Definition
Dense portion of the lateral scleratome
Term
where is the intervertebral disc of the forming vertebrae derived from?
Definition
compact portion of perinotochordal sheath
Term
What does the remaining notochord form
Definition
nucleus palposus
Term
where is the intersegmental artery and spinal nerve of the forming vertebrae derived from?
Definition
the loose part of the lateral scleratome
Term
Neurocentric junction
Definition
junction of cartilage between centrum of vertebrae and neural arches. allows for vertebrae to grow longitudinally. closes at 3-6 years of age
Term
Klippel Feil anomaly
Definition
Rare, recessive. several fused cervical vertebrae. short neck and low nuchal hair line. Other problems
Term
sacralization
Definition
Lumbar vertebrae fused with sacrum
Term
lumbarization
Definition
sacral vertebrae are unfused like the lumbar vertebrae. Has a negative effect on the stability of the spine
Term
Raschischisis
Definition
many vertebrae have unfused processes
Term
Spina bifida
Definition
series of conditions where one or few vertebrae have unfused processes. SB occulta is mildest form
Term
Hemivertebrae
Definition
piece of bone that throws off alignment of spine. May be do to failure of some primary ossification centers
Term
scoliosis
Definition
abnormal lateral curve of spine. 7X more common in females
Term
Sprengel anomaly
Definition
undecended scapula. remainas at around C4-T2. affects movement of shoulder
Term
Which skull bones ossify intramembraneously?
Definition
Calvaria, facial bones, jaw
Term
Which skull bones ossify endochondrially
Definition
chondrocranium, ossicles, styloid processes
Term
Dysraphic defect of skull
Definition
absence or opening between calvaria bones
Term
Closure of posterior and anteriorlateral fontanelles
Definition
2-3 monthes
Term
Closure of anterior fontanelle
Definition
1.5-2 years
Term
Closure of the posteriorlateral fontanelle
Definition
1 year
Term
Craniosynostosis
Definition
sutures close prematurely. Results in skull asymmetry. Skull grows in parallel with suture
Term
Cloverleaf skull
Definition
severe form of craniosynostosis. Skull grows in three directions
Term
microcephaly
Definition
small calvaria, normal face size. brain defect
Term
Craniovertebral Junction defects
Definition
involve bone fusions (like occipitalization of atlas) and/or loose ligaments. associated with torticollis, short neck, low nuchal hair line, and restricted movement of head and neck
Term
Marfan syndrome
Definition
Autosomal dominant. Spider-like, elongated digits. Aortic, eye, and spine abnormalities
Term
osteogenesis imperfecta
Definition
dominant. type I collagen defect
Term
Precursor for vascular smooth muscle
Definition
Local mesoderm (any mesoderm from surrounding area) and in parts of the head and neck, from neural crest mesenchyme
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