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Development of the Spinal Cord
Development of the Spinal Cord, Spinal Nerve, and the Role of Neural Crest Cells
25
Anatomy
Graduate
09/05/2011

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Term
The ventral column of gray matter in the spinal cord is also known as what during development? What populates it?
Definition
basal plate, somatic motor neurons
Term
What does the notochord ultimately become?
Definition
nucleus pulposus of intervertebral discs
Term
The dorsal column of gray matter in the spinal cord is also known as what during development? What populates it?
Definition
alar plate, association or interneurons that relay sensory information to appropriate areas of the CNS
Term
Located in the dorsal aspect of the basal plate in the thoracolumbar and sacral regions of the spinal cord this area contains the neurons of the sympathetic and parasympathetic nervous system of the ANS respectively.
Definition
intermediolateral cell column
Term
Neural crest cells are located where on the neural fold?
Definition
margins
Term
Fusion of the neural folds and formation of the neural tube is known as what?
Definition
neurulation
Term
The ____ portion of the neural tube is the developing brain and the _____ portion of the neural tube is the developing spinal cord
Definition
cranial, caudal
Term
neuroepithelium of the neural tube is supplanted by these cells from which neurons are formed.
Definition
neuroblasts
Term
These cells in the ventricles of the brain produce CSF.
Definition
ependymal
Term
neuroblasts which are destined to become neurons establish a _____ layer surrounding neuroepithelial cells which becomes the gray matter of the spinal cord
Definition
mantle layer
Term
What will happen to the dermamyotome for a given somite?
Definition
Will become muscle mass into which the axons of somatic motor neurons will terminate.
Term
Specializations on the tips of axons of motor neurons leaving the developing spinal cord that guide nerve fibers to their destination is known as what?
Definition
Growth cone
Term
What part of the growth cone sense chemical and physical markers?
Definition
filopodia
Term
Peripherally directed portions of sensory neurons and axons of somatic motor neurons join where during development?
Definition
spinal nerve
Term
The dorsal mass of cells in the somite is known as ____ and will become muscle where?
Definition
epimere, musculature of the neck and back
Term
The ventral mass of cells in the somite is known as ____ and will become what muscles?
Definition
hypomere, musculature of thoracic and abdominal walls
Term
At birth the spinal cord ends at vertebral level ____ and an adults spinal cord ends at vertebral level _____?
Definition
L3, L2
Term
Elongated dorsal and ventral roots of the lumbar and sacral spinal nerves to compensated for the distance between spinal level of origin and the vertebral level at which they exit are collectively called what?
Definition
Cauda equina
Term
Failure of the entire neural tube to close results in? If the problem is localized to a portion of the developing spinal cord? Restricted to cranial portion of neural tube?
Definition
Craniorachischisis totalis, partial rachischisis, anencephaly
Term
Congenital defect in the formation of the vertebral arch due to localized disruption of induction mechanisms in the lumbosacral region of the vertebral column.
Definition
spina bifida (occulta or cystica) usually L4-S1
Term
What are the two forms of spinabifida cystica?
Definition
Meningocele (herniation of the meninges), Meningomyelocele (herniation of the meninges and spinal cord that can lead to hydrocephaly)
Term
Special population of neuroepithelium located at the margin of neural plate and neural folds.
Definition
neural crest
Term
All peripheral ganglia in the thorax whether somatic or autonomic are derived from what cell type?
Definition
neural crest cells
Term
Neural crest cells that fail to migrate to their appropriate position can form catecholamine producing tumors known as?
Definition
pheochromocytoma
Term
Failure of neural crest cells to migrate into the walls of the large bowel resulting in an absence of peristalsis causes what disease?
Definition
Congenital Megacolon (Hirschprung's Disease)
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