Term
| What allows RBCs to change shape as they pass through vessel? |
|
Definition
| Spectrin (accounts for the flexibility and biconcave shape) |
|
|
Term
| What are some of the different causes of polycythemia? |
|
Definition
Excess erythropoeitin: Renal cell carcinoma, pheochromocytoma, hemangioblastoma, chronic hypoxia
Polycythemia vera
Down syndrome (65% at birth) |
|
|
Term
| What coagulation factor is deficient in Hemophilia A? |
|
Definition
|
|
Term
| What coagulation factor is deficient in hemophilia B? |
|
Definition
|
|
Term
| What clotting factors require vitamin K for synthesis? |
|
Definition
| X, IX, VII, II, Protein C, Protein S |
|
|
Term
| What are the tx for OD of heparin and warfarin? |
|
Definition
Hep: protamine sulfate
Warfarin: vitamin K or fresh frozen plasma |
|
|
Term
What lab value is used to monitor the following:
Heparin
Warfarin
enoxaparin |
|
Definition
Heparin: PTT
Warfarin: PT, INR(2-3)
enoxaparin: Factor Xa activity |
|
|
Term
| What is the tx for heparin induced thrombocytopenia |
|
Definition
| Anticoagulate with Lepirudin or bivalirudin |
|
|
Term
What pathologic RBC form would you see in the following disease:
Lead poisoning |
|
Definition
|
|
Term
What pathologic RBC form would you see in the following disease:
G6PD deficiency |
|
Definition
| Heinz bodies with bite cells |
|
|
Term
What pathologic RBC form would you see in the following disease:
DIC |
|
Definition
|
|
Term
What pathologic RBC form would you see in the following disease:
Abetalipoproteinemia |
|
Definition
|
|
Term
What pathologic RBC form would you see in the following disease:
Asplenia |
|
Definition
|
|
Term
What is the cause of anemia given the following statements:
Microcytic anemia + swallowing difficulty + glossitis |
|
Definition
| Iron deficiency; Plummer-Vinson syndrome |
|
|
Term
What is the cause of anemia given the following statements:
Microcytic anemia + >3.5 HbA2 |
|
Definition
|
|
Term
What is the cause of anemia given the following statements:
Megaloblastic anemia not correctable by B12 or Folate |
|
Definition
|
|
Term
What is the cause of anemia given the following statements:
Megaloblastic anemia along with peripheral neuropathy |
|
Definition
|
|
Term
What is the cause of anemia given the following statements:
Microcytic anemia + basophilic stippling |
|
Definition
Lead poisoning
ACD
B-thalassemia
Iron deficiency anemia |
|
|
Term
What is the cause of anemia given the following statements:
microcytic anemia reversible with B6 |
|
Definition
|
|
Term
What is the cause of anemia given the following statements:
HIV positive patient with macrocytic anemia |
|
Definition
|
|
Term
What is the cause of anemia given the following statements:
Normocytic anemia + red urine in the morning |
|
Definition
| Paroxysmal Nocturnal Hemoglobinuria |
|
|
Term
What is the cause of anemia given the following statements:
Normocytic anemia and elevated creatinine |
|
Definition
|
|
Term
| What is the rate limiting step in heme synthesis? |
|
Definition
| d-aminolevulinic synthase |
|
|
Term
| What is the cause of ITP? |
|
Definition
| anti-GpIIb/IIIa antibodies (platelet destruction) |
|
|
Term
| What is the defect in Bernard-Soulier disease? |
|
Definition
| deficiency GpIb (defect in platelet-collagen adhesion) |
|
|
Term
| What is the most common inherited bleeding disorder |
|
Definition
|
|
Term
| What are some of the hereditary syndromes of thrombosis |
|
Definition
Factor V Leiden (most common)
Prothrombin gene mutation
Antithrombin
Protein C or S deficiency |
|
|
Term
Hematologic tests/ findings:
Ham's test |
|
Definition
| Paroxysmal nocturnal hematuria |
|
|
Term
Hematologic tests/ findings:
DEB test |
|
Definition
|
|
Term
Hematologic tests/ findings:
Heinz bodies |
|
Definition
|
|
Term
Hematologic tests/ findings:
D-dimers |
|
Definition
|
|
Term
Hematologic tests/ findings:
Basophilic stippling |
|
Definition
|
|
Term
Hematologic tests/ findings:
Osmotic fragility test |
|
Definition
|
|
Term
Hematologic tests/ findings:
+ ristocetin test |
|
Definition
|
|
Term
| What is the most common type of nonHodgkins lymphoma in adults? Children? |
|
Definition
Adults: Diffuse large B cell
Children: Lymphoblastic |
|
|
Term
| What lab findings are indicative of DIC? |
|
Definition
elevated D-dimer
elevated PTT
Elevated bleeding time |
|
|
Term
What is the structure of HbH?
What disease results? |
|
Definition
Beta4
alpha thalassemia (severe) |
|
|
Term
| What is the structure of Hb Barts? |
|
Definition
|
|
Term
| What disease results in Hb Barts production? |
|
Definition
Hydrops fetalis
Severe a-thalassemia = death |
|
|
Term
| What are the causes of aplastic anemia |
|
Definition
Radiation
Benzene
Viruses
immune related
fanconi's anemia |
|
|
Term
| In what hematologic disease would you expect to see positive Coomb's test |
|
Definition
| Autoimmune hemolytic anemia |
|
|
Term
| What findings are a/w hereditary spherocytosis |
|
Definition
decreased spectrin
positive osmotic fragility test
Howell-Jolly bodies (after splenectomy)
Coomb's negative
Pigmented gallstones
jaundice |
|
|
Term
| A child who had been anemic since birth has been cured via splenectomy. What was the disease? |
|
Definition
|
|
Term
| What neoplasms are a/w AIDS |
|
Definition
Kaposi sarcoma
Invasive squamous cell carcinoma
CNS lymphoma
NonHodgkins lymphoma |
|
|
Term
| A heart failure patient is newly diagnosed with cancer and is being evaluated for chemo. What chemotherapeutic agent should be avoided in this patient? |
|
Definition
|
|
Term
| Chromosomal analysis of an anemia patient reveals Philadelphia chromosome (t9;22). Treatment? |
|
Definition
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