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Definition
shield exposed skin surface from harmful stimuli |
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absorb moisture from skin and local wounds to discourage bacterial growth |
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can alleviate irritation of mucous membranes |
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Definition
fat or oil substances used to increase moisture content of skin membranes |
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Definition
coagulate blood, help wounds and cuts heal quickly |
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Definition
increase skin temperature by increasing circulation at the surface |
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destroy skin at the applied site (warts, keratoses, hyperplastic tissue) |
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cause peeling of skin, useful in the treatment of eczema, acne, etc. |
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biological factors that effect absorption |
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Definition
skin age, skin condition, regional skin sites, skin metabolism, circulatory effects |
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Physiochemical factors that effect absorption |
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Definition
skin hydration, drug/skin binding, temperature penetration enhancers, drug/vehicle interaction, dosage form properties |
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Term
three components of topical dosage form |
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Definition
base or body of dosage form, medicinal agent, preservative |
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Definition
intended for topical use, local effects, deliver drug to skin for dermal disorders |
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Definition
1. hydrocarbon bases 2. absorption bases 3. emulsion bases (w/o) 4. emulsion bases (o/w) 5. water-miscible bases |
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Characteristics of Hydrocarbon Bases for Ointments |
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Definition
* insoluble in water * not water washable * will not absorb water * emollient * occlusive * greasy |
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Examples of Hydrocarbon Bases |
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Definition
Petrolatum (vasoline), white petrolatum, yellow ointment |
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