Term
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Definition
| Process by which a solid solute with relatively low solubility enters into a solution in the presence of a solvent |
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Term
| why is dissolution important |
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Definition
| bc of what we learned in particle size lecture |
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Term
| Describe history of dissolution |
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Definition
– First evidence : Noyes and Whitney 1897
– 20th century: Edwards proposed relationship between rate of dissolution of solid dosage form and absorption from GIT
– Allowed in vitro prediction of in vivo behavior or drug
– Mandatory by FDA now for pharmaceutical products |
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Term
| What are some factors that affect dissolution |
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Definition
– Physicochemical parameters of the drug and the dosage form
– Affinity between the drug and the solvent in which it is dissolved
– Swelling process
– Solvent penetration
– Wettability
– Disintegration
– Deaggregation |
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Term
| Drug needs to be in _______ for it to exert its therapeutic action |
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Definition
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Term
| Dissolution rate could be the __________ in absorption in many cases e.g. oral solid dosage forms |
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Definition
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Term
| Any change in dissolution could lead to change in ___________ |
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Definition
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Term
| Dissolution rate can be increased in _______ particle size , _______ ________ in diffusion layer by using salts of the parent compound |
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Definition
| decreasing andincreasing solubility |
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Term
| Within the Diffusion Layer Model, Dissolution of drugs results from _________ |
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Definition
| the fine product form of the powder |
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Term
| Within the Diffusion Layer Model Drug in solution absorbed through.... |
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Definition
| GIT into systemic circulation |
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Term
| Within the Diffusion Layer Model the driving force is the __________ ___________ between these two layers |
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Definition
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Term
| The rate of dissolution is expressed by |
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Definition
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